objectives: crocin and safranal, the major constituents of saffron, exert neuroprotective effects. in the present study, we investigated the effects of crocin and safranal  (alone or in combination with insulin) on peripheral neuropathy in diabetic rats. materials and methods: diabetes was induced by intraperitoneal (i.p.) injection of 60 mg/kg of streptozotocin (stz) and confirmed by blood glu...

because of less systemic side effects of topical medications in pain relief of the painful form of diabetic peripheral neuropathy, this study aimed to compare the effect of amitriptyline and capsaicin cream in relieving pain in this condition. in this randomized, double-blind and non -inferiority trial, 102 patients received amitriptyline 2% and capsaicin 0.75% creams  3 times a day for 12 week...

Objectives: This study reports the effectiveness of acupuncture and moxibustion for Diabetic Peripheral Neuropathy concurrent with Chemotherapy-Induced Neuropathy.Case presentation: A 58-year-old male was admitted hand numbness foot pain after his sixth chemotherapy. He treated 18 days. Symptoms were evaluated a numeric rating scale (NRS). After days treatment, improved from NRS 4 to 2. His dis...

the aim of the present study was to evaluate the effect of ethanolic extract of murraya koenigii leaves (mkl) on blood glucose level and in prevention or management of diabetic neuropathy. in the present study the diabetic neuropathy was developed 9 weeks after single injection of streptozotocin (stz, 70 mg/kg i.v.) in rat. the treatment with mkl (300 and 500 mg/kg p.o.) was started after stabi...

abstract objective: diabetic peripheral neuropathy is the main risk factor of diabetic foot ulcer and its early diagnosis is important to prevent limb amputation. we assessed the prevalence of peripheral neuropathy in diabetic patients. materials and methods: this cross-sectional study was performed on 352 randomly selected diabetic patients using a standardized questionnaire including age, gen...

normal 0 false false false en-us x-none ar-sa background: diabetes mellitus (dm) is a common metabolic disorder that can cause various complications including, peripheral neuropathy (pnp). some possible risk-factors such as blood glucose level, hyperglycemia, duration of diabetes, and lipid profiles are assumed to be important in diabetic pnp incidence. the aim of this study is to evaluate the ...

Diabetic neuropathy is the most common chronic complication of diabetes. Among the three major complications of diabetes, diabetic neuropathy is frequent and appears earliest after the onset of diabetes. Diabetic neuropathy presents various clinical symptoms from head to toe (and sole). Identification of the early signs of neuropathy in diabetic patients, early diagnosis, and appropriate manage...