AIM Diabetes is accompanied by abdominal obesity, which produces various metabolic abnormalities. While metabolic factors have been considered to promote the development of coronary atherosclerosis in the early-stage of diabetes, it remains unknown whether the presence of obesity in early-stage diabetics affects the natural history of coronary atherosclerosis. We herein investigated the charact...

BACKGROUND The emerging role of TLR2/4 as immuno-metabolic receptors points to key involvement of TLR/IL-1R/MyD88 pathway in obesity/type-2 diabetes (T2D). IL1R-associated kinase (IRAK)-1 is a critical adapter protein (serine/threonine kinase) of this signaling pathway. The changes in adipose tissue expression of IRAK-1 in obesity/T2D remain unclear. We determined modulations in IRAK-1 gene/pro...

A prospective study of various coronary and contributory risk factors in urban and rural diabetic population is presented. For the coronary risk factors, smoking prevalence was high for urban diabetics (27%), also high TC levels (57%), and low levels of HDL cholesterol (17%) were comparatively greater in urban diabetics. Prevalence of hypertension was higher, (40%) in rural diabetics. High LDL ...

Clinical studies were carried out on 526 out-patients with diabetes mellitus on whom the progress of the disease could be followed up for more than 5 years (average 10.3 years). The results obtained were as follows: (1) Ischemic ECC abnormality was noted at a higher frequency in the obese group than in the non-obese group. Even when comparisons were made of the same condition based on the durat...

BACKGROUND/AIM [corrected] Oxidative stress plays a critical role in the pathogenesis of various diseases. Recent reports indicate that obesity may induce systemic oxidative stress. The aim of the study was to potentiate oxidative stress as a factor which may aggravate peripheral insulin sensitivity and insulinsecretory response in obesity in this way to potentiate development of diabetes. The ...

BACKGROUND Betatrophin has been suggested as an inducer of β-cell proliferation in mice in addition to its function in regulating triglyceride. Recent data showed that betatrophin was increased in Type 2 Diabetes (T2D), however, its ability to induce insulin production has been questioned. We hypothesized that the increased betatrophin in T2D is not affecting insulin production from β-cells. To...

Fifty seven newly diagnosed obese maturity onset diabetics were studied for 3 years to monitor the effect of diabetic control on weight and blood lipids. Of the 41 patients who had a satisfactory control of diabetes, weight loss of a modest degrec was recorded in only 6. The blood lipids did not show any significant changes in both the controlled and uncontrolled groups. It is suggested that bl...

Background and objectives: Adipose tissue is responsible for releasing various adipokines which have been related to insulin resistance. Understanding the relationship of these adipokines to insulin resistance may help in early diagnosis and faster the development of new treatments for diabetes. The objective of this study was to determine the possible association between these adipokines (visf...