نتایج جستجو برای: diffuse cutaneous scleroderma
تعداد نتایج: 124685 فیلتر نتایج به سال:
A 51-year-old female developed linear-like scleroderma in the left thigh following a linear wound caused by a car accident. 27 years later she also developed a typical diffuse cutaneous systemic sclerosis with extensive skin involvement and bibasilar pulmonary fibrosis. The second case is a 39-year-old female who had a history of Raynaud's phenomenon since early childhood. She developed a morph...
Systemic sclerosis (scleroderma; SSc) is divided further into limited cutaneous disease and diffuse cutaneous disease on the basis of the extent of skin thickening. Limited disease is defi ned as skin thickening that only affects the extremities below the elbows and/or below the knees. Diffuse cutaneous disease is defi ned as skin thickening proximal to the elbows/or knees in addition to distal...
ABSTRACT Systemic sclerosis classified to limited and diffuse types. Skin and visceral involvement is more sever and progressive in diffuse form and also pericardial effusion is more frequent in diffuse type of disease. There is only few case reports of symptomatic pericardial effusion in limited type. In this article we represented a case of limited systemic sclerosis (scleroderma...
Here, we describe an atypical case of systemic sclerosis in its diffuse cutaneous form with acute and rapid progression of the cutaneous condition, without any systemic manifestations and the infrequent formation of bullae, showing the importance of diagnosis and early treatment in such cases. This case also shows that special measures should be taken for bullous cutaneous lesions and ulceratio...
Transforming growth factor-ß (TGF-ß) signaling is implicated in the pathogenesis of fibrosis in scleroderma or systemic sclerosis (SSc), but the precise mechanisms are poorly understood. The immediate-early gene Egr-1 is an inducible transcription factor with key roles in mediating fibrotic TGF-ß responses. To elucidate Egr-1 function in SSc-associated fibrosis, we examined change in gene expre...
OBJECTIVE To determine the frequency of pericardial and pleural effusions in scleroderma. METHODS Using a case-control format, patients with scleroderma and no known cardiac disease were recruited. Echocardiograms and chest radiographs were performed. Age- and gender-matched controls had echocardiograms performed which were read by a cardiologist, blinded to the diagnosis. The medical records...
Systemic sclerosis is a rare autoimmune disorder with a wide spectrum of clinical manifestations and a multitude of autoantibodies that are associated with it. In the past several years, advances in serologic testing have led to research indicating important prognostic and phenotypic associations with certain subsets of autoantibodies. In particular, anti-RNA polymerase III (anti-RNAP III) has ...
Experience suggests that African Americans may express autoimmune disease differently than other racial groups. In the context of systemic sclerosis (scleroderma), we sought to determine whether race was related to a more adverse expression of disease. Between January 1, 1990, and December 31, 2009, a total of 409 African American and 1808 white patients with scleroderma were evaluated at a sin...
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