While Distance Weighted Discrimination (DWD) is an appealing approach to classification in high dimensions, it was designed for balanced datasets. In the case of unequal costs, biased sampling, or unbalanced data, there are major improvements available, using appropriately weighted versions of DWD (wDWD). A major contribution of this paper is the development of optimal weighting schemes for var...

The computational sampling of rare, large-scale, conformational transitions in proteins is a well appreciated challenge-for which a number of potentially efficient path-sampling methodologies have been proposed. Here, we study a large-scale transition in a united-residue model of calmodulin using the "weighted ensemble" (WE) approach of Huber and Kim. Because of the model's relative simplicity,...

Over the last 10 years, diffusion-weighted imaging (DWI) has become an important tool to investigate white matter (WM) anomalies in schizophrenia. Despite technological improvement and the exponential use of this technique, discrepancies remain and little is known about optimal parameters to apply for diffusion weighting during image acquisition. Specifically, high b-value diffusion-weighted im...

In 1988 Ronald R. Yager [14] introduced a new aggregation technique based on the ordered weighted averaging (OWA) operators. The goal of this paper is to present a short survey of of OWA operators and illustrate their applicability by a real-life example.

BACKGROUND Geographically weighted regression (GWR) is a modelling technique designed to deal with spatial non-stationarity, e.g., the mean values vary by locations. It has been widely used as a visualization tool to explore the patterns of spatial data. However, the GWR tends to produce unsmooth surfaces when the mean parameters have considerable variations, partly due to that all parameter es...

This talk will shed some first light on the two imaging concepts diffusion weighted imaging (DWI) and perfusion weighted imaging (PWI). On the one side one may criticize that for the lecture time given, this will definitely be an incredible or even impossible task: To give sufficient credit to both of these importantant imaging concepts. On the other side one could say: ’Come on, let’s talk abo...

Previously, we introduced the best-expert problem, and we proved a O(ln K) mistake bound for the majority vote algorithm when a perfect expert exists, i.e., there is an expert that never makes mistakes. Now let us turn to the more realistic case where there is no perfect expert among the committee. We extend the majority vote algorithm with a confidence weight. At each round, we maintain a weig...

The application of geographically weighted regression (GWR) - a local spatial statistical technique used to test for spatial nonstationarity - has grown rapidly in the social, health and demographic sciences. GWR is a useful exploratory analytical tool that generates a set of location-specific parameter estimates which can be mapped and analysed to provide information on spatial nonstationarity...

Ecological security is an important research topic, especially urban ecological security. As highly populated eco-systems, cities always have more fragile ecological environments. However, most of the research on urban ecological security in literature has focused on evaluating current or past status of the ecological environment. Very little literature has carried out simulation or prediction ...