Antibiotic-resistant Staphylococcus aureus is of great concern, as it causes a wide range of life-threatening infections. The current study demonstrates that dihydropyrrolone (DHP)-coated polyacrylamide substrates are effective in reducing the number of culturable clinical isolates of S. aureus in vitro in a dose-dependent manner and are able to reduce the pathogenic potential of staphylococcal...

AIM To compare the effects of cytostatic compound dihydropyrrol derivative (D1, 5-amyno-4-(1,3-benzothyazol-2-yl)-1-(3-methoxyphenyl)-1,2-dihydro-3Н-pyrrol-3-one) and 5-fluorouracil (5-FU) on the normal colonic mucosa of tumor-bearing rats and to estimate the relationships between proliferation of normal colonic mucosa and tumor growth parameters. METHODS 1,2-dimethylhydrazine (DMH) carcinoge...

Aging and the progression of certain degenerative diseases are accompanied by increases in intracellular fluorescent material, termed "lipofuscin" and ceroid, respectively. These pigments are observed within granules composed, in part, of damaged protein and lipid. Modification of various biomolecules by aldehyde products of lipid peroxidation is believed to contribute to lipofuscin and ceroid ...

The X-ray structures of three simple heterocyclic compounds have been obtained for the first time. Structures both 3-acetyloxazolidin-2-one 1 and its unsaturated analogue 3-acetyloxazolin-2-one 3 show a planar imide nitrogen with exocyclic C=O oriented anti to ring N–C(=O) bond negligible intermolecular interactions, pattern consistent previously reported analogues. In contrast parent NH hetero...

In the title compound, C(12)H(13)N(3)O(2)S, the oxazolidin ring displays an envelope conformation. The dihedral angle between the benzimidazole ring and the 1,3-oxazolidin-2-one mean plane is 69.85 (13)°. In the crystal, mol-ecules are linked by inter-molecular N-H⋯N hydrogen bonds, forming a chain parallel to the b axis.

In the title compound, C(9)H(8)N(2)O(4), the indolin-2-one ring system is substanti-ally planar [maximum deviation = 0.0353 (15) Å]. In the crystal structure, inter-molecular N-H⋯O and O-H⋯O hydrogen bonds are responsible for the formation of a three-dimensional network.