• duchenne muscular dystrophy o onset 3 to 5 yrs o clinical § weakness o distribution § proximal > distal § symmetric § legs & arms § most involved muscles: adductor magnus in legs § relatively spared muscles: gracilis & sartorius o course § reduced motor function by 2 to 3 years § steady decline in strength: after 6 to 11 years o gowers sign: standing up with the aid of hands pushing on knees ...

Dilated cardiomyopathy is a prevalent and often fatal disease in humans and dogs. Indeed dilated cardiomyopathy is the third most common form of cardiac disease in humans, reported to affect approximately 36 individuals per 100,000 individuals. In dogs, dilated cardiomyopathy is the second most common cardiac disease and is most prevalent in the Irish Wolfhound, Doberman Pinscher and Newfoundla...

Dilated cardiomyopathy is a frequent cause of heart failure and death. Atrial natriuretic peptide (ANP) is a biomarker of dilated cardiomyopathy, but there is controversy whether ANP modulates the development of heart failure. Therefore, we examined whether ANP affects heart failure, cardiac remodeling, function, and survival in a well-characterized, transgenic model of dilated cardiomyopathy. ...

OBJECTIVES To compare HLA distribution in familial and non-familial dilated cardiomyopathy, because a serum marker that could identify families at risk of developing dilated cardiomyopathy should be of use in screening for the disease. PATIENTS 100 patients with dilated cardiomyopathy. METHODS 200 first degree relatives from 56 of the proband families were screened for dilated cardiomyopath...

Background: Dilated cardiomyopathy (DCM) is revealed with the left ventricular dilatation and systolic dysfunction. This study was performed to determine the level of Calcitonin Gene Related Peptide (CGRP) and Brain Natriuretic Peptide (BNP) in children with dilated cardiomyopathy and controls and comparison of these two biomarkers in patients. Materials and Methods: This case-control study was...

BACKGROUND The prevalence of myocarditis and cardiotropic viral infection in human immunodeficiency virus (HIV)-associated cardiomyopathy is unknown in Africa. METHODS Between April 2002 and December 2007, we compared the prevalence of myocarditis and cardiotropic viral genomes in HIV-associated cardiomyopathy cases with HIV-negative idiopathic dilated cardiomyopathy patients (i.e. negative c...

Cardiac interstitial fibrosis may contribute to ventricular dysfunction and the prognosis of patients with dilated cardiomyopathy. The objective of the present study was to determine if total myocardial collagen content and collagen type III/I (III/I ratio) mRNAs differ in hypertensive, alcoholic, and idiopathic dilated cardiomyopathy subjects. Echocardiography and exercise cardiopulmonary test...

conclusions the hormonal levels were low in patients with idiopathic dilated cardiomyopathy. however, the prognostic significance of different hormonal deficiencies was not clear in our study populations who were receiving standard therapies for heart failure and had a relatively stable clinical condition. results except for testosterone level, the levels of gh, igf-1, t3, and t4 concentrations...

conclusions diagnosis of tachycardia-induced cardiomyopathy in children is important, since appropriate treatment improves the prognosis. every child with recurrent and persistent palpitation with the first episode of congestive heart failure should be evaluated for tachycardia- induced cardiomyopathy. introduction tachycardia-induced cardiomyopathy (tic) is a ventricular dysfunction secondary ...