2014 Anal fissure is a common painful anorectal condition which affects people of various age groups, and deteriorates their quality of life. Chronic anal fissure requires medical intervention either by pharmacotherapy or by surgery. Various pharmacological agents have been used in the treatment of chronic anal fissure with the aim of relaxation of internal anal-sphincter smooth muscle. Diltiaz...

Introduction: Fissure-in-ano is an ulcer in the longitudinal axis of lower anal canal. It having prevalence about 17.91%. By seeing signs and symptoms we can consider it as one among six varieties Dushta Vrana i.e., Pittaja Dustavrana. Due to busy life schedules people don’t prefer hospitalization other operative procedures. So, there a need find out new simpler medicament which enables easy be...

AIM To assess the value of using smooth muscle relaxants drugs and assess the results of the topical use of 2% diltiazem as an alternative to 0.2% nitroglycerin in the treatment of chronic anal fissure (CAF). METHODS Review of the CAF contained in a prospectively collected database of anal fissures including one hundred forty-five patients diagnosed with CAF and treated with standard measures...

AIM To compare surgical and chemical sphincterotomy for treatment of chronic anal fissure. METHODS The 160 patients studied were randomly divided into four equal groups, treated by lateral internal sphincterotomy (group S), local diltiazem ointment (group D), local glyceryl trinitrate ointment (group GTN), or injection of botulinum toxin into the internal anal sphincter (group BT). Anal manom...

conclusions lidocaine-meperidine-diltiazem gel provides significantly better pain control than lidocaine-diltiazem gel and lidocaine gel alone during transrectal ultrasound guided prostate biopsy and probe insertion. this mixture gel is safe, easy to administer and well accepted by patients. results the mean of visual analog pain scale was 4.5 in group a, 3.5 in group b, and 2.0 in group c duri...

Objective: To compare the mean pain scores after hemorrhoidectomy in patients given topical calcium channel blocker and being routine post-operative treatment only. Study Design: Randomized Controlled Trial. Setting: Surgical Department of Holy Family Hospital. Period: 7th January 2022 to July 2022. Material & Methods: Patients fulfilling inclusion criteria were divided into two groups. Gro...

cyclosporine (csa) is a drug that has been used for prevention of kidney transplant rejection for many years. diltiazem with the inhibition of cyclosporine metabolism and clearance will increase csa concentration and csa dose can be decreased. the aim of this study was the evaluation of diltiazem effect on csa dose adjustment with respect to c2. forty stable renal transplant patients who were r...