We describe a high-throughput method, named ChIP-SNP, for the identification of allele-specific protein-DNA interactions throughout the human genome. ChIP-SNP combines chromatin immunoprecipitation (ChIP) with whole-genome single nucleotide polymorphism (SNP) genotyping microarray analysis. We demonstrated that it can be used to accurately identify allele-specific binding of RNA polymerase II (...

We use G-stable pieces to construct some equidimensional varieties and as a consequence, obtain Lusztig’s dimension estimates [L2, section 4]. This is a generalization of [HL]. In Lemma 1.1 and Proposition 1.2, we assume that G is arbitrary connected algebraic group and G̃ is an algebraic group with identity component G. Lemma 1.1. Let g ∈ G̃. Define i : G̃ → G̃ by i(h) = ghgıhı. For any closed sub...

If P and Q are partial orders, then the dimension of the cartesian product P x Q does not exceed the sum of the dimensions of P and Q. There are several known sufficient conditions for this bound to be attained, on the other hand, the only known lower bound for the dimension of a cartesian product is the trivial inequality dim(P x Q) ~> max{dim P, dim O}. In partictdar, if P has dimension n, we...

The present study was conducted to study the effect of protected-glutamine (Gln) supplementation on dry matter intake (DMI), milk yield (MY) and composition, somatic cell counts (SCC) and blood parameters in fresh cows. Forty Holstein cows at zero day of parturition (calving day = day 0) were divided into four groups (n=10), and fed (ad libitum) with one of the diets including: basal d...

Methylation of DNA and of Lysine 9 on histone H3 (H3K9) is associated with gene silencing in many animals, plants, and fungi. In Neurospora crassa, methylation of H3K9 by DIM-5 directs cytosine methylation by recruiting a complex containing Heterochromatin Protein-1 (HP1) and the DIM-2 DNA methyltransferase. We report genetic, proteomic, and biochemical investigations into how DIM-5 is controll...