The mono-epoxidation of geraniol by dimethyldioxirane was carried out in various solvents. In all cases, the product ratios for the 2,3 and 6,7 mono-epoxides were in agreement with literature values. Kinetic studies were carried out at 23 degrees C in the following dried solvent systems: acetone (k(2) = 1.49 M(-1)s(-1)), carbon tetrachloride/acetone(9/1, k(2)=2.19 M(-1)s(-1)), and methanol/acet...

The chemical behavior of various oligoenes 2 has been studied. The catalytic hydrogenation of diene 3 yielded monoene 4. Triene 7 was hydrogenated to diene 8, monoene 9 and saturated hydrocarbon 10. Bromine addition to 3 and 7 yielded the dibromides 17 and 18, respectively, i.e., the oligoene system has been attacked at its terminal olefinic carbon atoms. Analogously, the higher vinylogs 19 and...

17beta-estradiol (E2), estrone and diethylstilbestrol (DES) had no effect on nuclear and nucleolar RNA synthesis in vitro. However, after reacting with dimethyldioxirane (DMDO), a versatile epoxide-forming oxidant, these estrogens were able to inhibit and in a dose-dependent manner nuclear and nucleolar RNA synthesis in vitro. It was also found that the time required for the maximal activation ...