نتایج جستجو برای: dipeptide
تعداد نتایج: 3045 فیلتر نتایج به سال:
1. The absorption of lysine and two lysine-containing dipeptides was studied in normal and cystinuric subjects by jejunal perfusion. Absorption of each dipeptide was compared with that of its constituent amino acids. 2. In normal subjects lysine was better absorbed from the dipeptide glycyl-L-lysine than from the equivalent amino acid mixture. In cystinuric patients lysine was absorbed very poo...
for better understanding of conformational stability of the dipeptide model hco—gly—l—leu—nh2,ab initio and dft computations at hf/6-31g(4 6-311++g(d,p) and b3lyp/6-31g(d) levels oftheory were carried out. geometry optimization of the dipeptide within the leucine (leu) side chainangles (x2 ,x2) resulted in three stable conformations as followings: anti-anti, the most stable one,(xi = 180°, x2 =...
PURPOSE To characterize proton-driven carrier-mediated dipeptide uptake in primary cultured conjunctival epithelial cells of the pigmented rabbit using beta-alanyl-L-histidine (L-carnosine) as a model dipeptide substrate. METHODS Uptake of tritiated L-carnosine was monitored using conjunctival epithelial cells on days 6 through 8 in culture on a filter support. The structural features of dile...
In this research, dipeptide (his-β-alanine) and porphyrin derivatives were choosen for comparing chelating ability of toxic metals such as Al3+, Cu2+, Hg2+ and Pb2+ in vitro. The reason for choosing these two compounds is that both of them are naturally present in biological systems and comparison of chelating ability of these two compounds has not yet been done. Synthesis and comparison of kin...
Dipeptide (Leu-Leu) and nitrate transport activities of 26 Arabidopsis NPF (NRT1/PTR Family) proteins were screened in Saccharomyces cerevisiae and Xenopus laevis oocytes, respectively. Dipeptide transport activity has been confirmed for 2 already known dipeptide transporters (AtNPF8.1 and AtNPF8.3) but none of the other tested NPFs displays dipeptide transport. The nitrate transport screen res...
T robust expression of microbial pattern recognition receptors such as TLR4 and Nod2 in intestinal stem cells reflects an active communication dynamic between the host and the gut microbiota. A new study reveals that muramyl dipeptide, the bacterial cell wall peptidoglycan motif, activates Nod2 within crypt base columnar Lgr5positive stem cells and promotes their survival. Apart from the immedi...
Dipeptide esters of paracetamol were prepared in high yields. These compounds are quantitatively hydrolyzed to paracetamol and corresponding 2,5-diketopiperazines at pH 7.4 and 37 degrees C. The reactivity is increased in sarcosine and proline peptides and decreased by bulky side chains at both the N- and C-terminal residues of the dipeptide carrier. Moreover, dipeptide esters of paracetamol di...
Here we report a systematic approach for predicting subcellular localization (cytoplasm, mitochondrial, nuclear, and plasma membrane) of human proteins. First, support vector machine (SVM)-based modules for predicting subcellular localization using traditional amino acid and dipeptide (i 1) composition achieved overall accuracy of 76.6 and 77.8%, respectively. PSI-BLAST, when carried out using ...
A dipeptide of unknown amino acid composition was subjected to acid hydrolysis and heat to permit breakage of peptide bonds in the sample resulting in each individual amino acid constituent. Chromatography was then employed with a proper solvent system to compare a set of known amino acid standards against the unknown hydrolyzed sample to determine the two amino acids present in the unknown dip...
Nucleotide binding and oligomerization domain-containing protein 2 (NOD2/Card15) is an intracellular protein that is involved in the recognition of bacterial cell wall-derived muramyl dipeptide. Mutations in the gene encoding NOD2 are associated with inherited inflammatory disorders, including Crohn disease and Blau syndrome. NOD2 is a member of the nucleotide-binding domain and leucine-rich re...
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