OBJECTIVES Recent developments of new direct oral anticoagulants that target specific clotting factors necessitate understanding of coagulation biology. The objective of this tutorial is to offer dental professionals a review of coagulation mechanisms and the pharmacodynamics of the conventional and new oral anticoagulants. Also, we summarized the dental implications of the conventional and new...

Direct oral anticoagulants targeting specific coagulation factors have been introduced as alternatives to conventional anticoagulants for both prophylactic and therapeutic indications. They have succeeded in overcoming the limitations of vitamin K antagonists. Although the favourable efficacy and side-effect profiles compared to vitamin K antagonists is proven, there is significant concern abou...