The physicochemical properties relevant to biological activity of selected bisphosphonates such as clodronate disodium salt, etidronate disodium salt, pamidronate disodium salt, alendronate sodium salt, ibandronate sodium salt, risedronate sodium salt and zoledronate disodium salt were determined using in silico methods. The main aim of our research was to investigate and propose molecular dete...

The solubility of disodium terephthalate in aqueous sodium hydroxide and hydroxide–ethylene glycol mixtures was determined experimentally by temperature analysis, gravimetry titration. experimental results were compared with existing literature data the phase diagrams from −25 to 70 °C. has no considerable dependence on temperature. freezing points solutions vary composition like any other solu...

the use of accelerated temperature stability studies using the arrhenius relationship is routine for estimating the stability of a drug at room temperature. therefore, the acceleration method is used to determine the expiration date of dexamethasone aqueous formulation manufactured in iran. a high-performance liquid chromatography (hplc) method utilizing ultraviolet (uv) detection for dexametha...

The use of accelerated temperature stability studies using the Arrhenius relationship is routine for estimating the stability of a drug at room temperature. Therefore, the acceleration method is used to determine the expiration date of dexamethasone aqueous formulation manufactured in Iran. A high-performance liquid chromatography (HPLC) method utilizing ultraviolet (UV) detection for dexa...

Gadoxetate disodium is a widely used magnetic resonance (MR) contrast agent for liver MR imaging, and it provides both dynamic and hepatobiliary phase images. However, acquiring optimal arterial phase images at liver MR using gadoxetate disodium is more challenging than using conventional extracellular MR contrast agent because of the small volume administered, the gadolinium content of the age...

By SANFORD LEIKIN AND SAMUEL P. BESSMAN D ISODIUM ETHYLEXEDIAMINE TETRAACETATE (EDTA) has beets known for some time to prolong coagulation in vitro.’3 During the course of treatment of seven patiemits for lead ititoxication with disodium calcium EDTA, we noted mio hemorrhagic mamiifestations.4’ However, Wishimisky6 described hypoprothrombimsemia appearing its a patiemit treated with disodium ca...

By SANFORD LEIKIN AND SAMUEL P. BESSMAN D ISODIUM ETHYLEXEDIAMINE TETRAACETATE (EDTA) has beets known for some time to prolong coagulation in vitro.’3 During the course of treatment of seven patiemits for lead ititoxication with disodium calcium EDTA, we noted mio hemorrhagic mamiifestations.4’ However, Wishimisky6 described hypoprothrombimsemia appearing its a patiemit treated with disodium ca...

In 13 patients with allergic asthma disodium cromoglycate protected fully only two from an allergen-induced asthmatic attack.Inhalation of disodium cromoglycate did not improve lung function in five patients with long-standing chronic asthma.Previous clinical trials do not show convincing evidence that this drug improves bronchial asthma in a high percentage of cases, but it seems to help a sma...