In vitro dissolution methodologies that adequately capture the oral bioperformance of solid dosage forms are critical tools needed to aid formulation development. Such methodologies must encompass important physiological parameters and be designed with drug properties in mind. Two-phase dissolution apparatuses, which contain an aqueous phase in which the drug dissolves (representing the dissolu...

In geology and daily life, kinetics and dynamics of particle (including crystal, droplet, and bubble) dissolution or growth in a liquid are a large class of often-encountered problems. The growth or dissolution of bubbles and drops are usually controlled by mass transfer, whereas the growth or dissolution of crystals may be controlled either by mass or heat transfer or by interface reaction. In...

The leaching kinetics of smithsonite ore in acetic acid solutions, an environmental friend, and natural reagent was investigated. The influence of parameters such as reaction temperature, particle size, solid-liquid ratio and acid concentration was studied in order to reveal the leaching kinetics of smithsonite ore. In this study, experimental and statistical methods were carried out in order t...

Oral dosage forms containing 300 mg theophylline in matrix-type tablets were prepared by direct compression method using two kinds of matrices – glycerylbehenate (hydrophobic) and hydroxypropylmethyl cellulose (hydrophilic). The in vitro release kinetics of these formulations were studied at pH 6.8 using the USP dissolution apparatus with the paddle assemble. The kinetics of the dissolution pro...

Oral dosage forms containing 300 mg theophylline in matrix type tablets, were prepared by direct compression method using two kinds of matrices, glycerylbehenate (hydrophobic), and (hydroxypropyl)methyl cellulose (hydrophilic). The in vitro release kinetics of these formulations were studied at pH 6.8 using the USP dissolution apparatus with the paddle assemble. The kinetics of the dissolution ...

In vitro release kinetics of three commercially available sustained release tablets (SR) diltiazem hydrochloride were studied at pH 1.1 for 2 h and for another 6 h at pH 6.8 using the USP dissolution apparatus with the paddle assemble. The kinetics of the dissolution process was studied by analyzing the dissolution data using five kinetic equations: the zero-order equation, the first-order equa...

The dissolution characteristics of melt granulations of paracetamol in capsule and tablet dosage form were compared to determine whether the dissolution characteristics of the granules can be actualized by formulating them as rapidly disintegrating tablets. The term melt granulation refers here to the wax-matrix granules that were formed by triturating the drug powder (paracetamol) with a melte...