BACKGROUND Secoisolariciresinol diglucoside (SDG), the main lignan in whole grain flaxseed, is a potent antioxidant and free radical scavenger with known radioprotective properties. However, the exact mechanism of SDG radioprotection is not well understood. The current study identified a novel mechanism of DNA radioprotection by SDG in physiological solutions by scavenging active chlorine speci...

Previous studies demonstrated that Kit activation confers radioprotection. However, the mechanism by which Kit signaling interferes with cellular response to ionizing radiation (IR) has not been firmly established. Based on the role of the sphingomyelin (SM) cycle apoptotic pathway in IR-induced apoptosis, we hypothesized that one of the Kit signaling components might inhibit IR-induced ceramid...

OBJECTIVES To analyze the results of an initiative aimed at improving the reasonable use of radiological examinations, ensuring their technical quality, implementing a radioprotection campaign that includes training of the professional team, and introducing the radioprotection card for children under 12 years old as a tool for parents and doctors to control children's exposure to radiation. M...

Tocopherol succinate (TS) has been shown to protect mice against acute radiation syndrome, however, its exact mechanism of action and its possible use in humans has not yet been evaluated. Our approach has been to test the radioprotectant properties of TS on CD34-positive stem cells from healthy volunteers. We hypothesize that a radioproteomics strategy can identify a drug-dependent, personaliz...

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a strong desmoplastic reaction where the stromal compartment often accounts for more than half of the tumor volume. Pancreatic stellate cells (PSC) are a central mediator of desmoplasia. There is increasing evidence that desmoplasia is contributing to the poor therapeutic response of PDAC. We show that PSCs promote radioprotection and ...

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a strong desmoplastic reaction where the stromal compartment often accounts for more than half of the tumor volume. Pancreatic stellate cells (PSC) are a central mediator of desmoplasia. There is increasing evidence that desmoplasia is contributing to the poor therapeutic response of PDAC. We show that PSCs promote radioprotection and ...

F o r m I (underwound families irradiated with fission neutrons at 32OC (in T E buffer) followed the expected expotential dependence on dose. The radiation sensitivity was found to be linearly related t o the average DNA linking difference (DL) with larger DL associated with enhanced r a d i a t i o n sensitivity. WR-33278, a radioprotector, is s h o w n t o s t i m u l a t e e u k a r y o t i ...

La Licence professionnelle en Radioprotection et Sûreté Nucléaire de l’IUT d’Aix Marseille possède son propre chantier école radioprotection ; EXTREME pour EX position des TR availleurs E n M ilieu nucléair . Cette plateforme comprend l’intégralité éléments d’une Installation Base depuis les vestiaires jusqu’à la sortie zone contrôlée permettant ainsi aux étudiants développer compétences métier...