1 Introduction Magnetoencephalography (MEG) is currently used clinically for presurgical localization of epileptic tissue, based on signals from interictal spikes, using single equivalent current dipole (ECD) modeling [1,2,3,4]. There has been a long-standing question " Do interictal spikes co-localize to the same area as epileptic seizures? " Minassin, et al. found that the interictal MEG loca...

Human cell extracts perform an aberrant form of DNA synthesis on methylated plasmids [1], which represents processing of O6-methylguanine (O6-meG). Here, we show that extracts of colorectal carcinoma cells with defects in the mismatch repair proteins that normally correct replication errors do not carry out this synthesis. hMSH2-defective LoVo cell extracts (hMSH for human MutS homologue) perfo...

For some TLE patients that do not respond the pharmacological treatment, epilepsy surgery is an option. In those cases, the determination of the location of the sources and the sequence in which they become active is of prime importance. In this paper, we investigate the interpretability and validity of dipole source localization based on EEG, MEG and simultaneous EEG+MEG for TLE interictal spi...

Magnetoencephalography (MEG) is a non-invasive method for studying magnetic fields generated by simultaneously firing neurons outside the skull. The skull, scalp and brain tissue do not distort magnetic fields, so the cortical activity can be easily measured. MEG is starting to be used to explore the effects of various psychopharmacological agents on resting brain, sensory and cognitive process...

Thrombopoietin (Tpo), the ligand for the c-Mpl receptor, is a major regulator of megakaryopoiesis. Treatment of mice with Tpo raises the platelet count fourfold within a few days. Conversely, c-mpl knock-out mice have platelet counts that are 15% that of normal. The subunit structure of the c-Mpl receptor is not fully understood. Some cytokines that stimulate megakaryopoiesis (IL-6, IL-11, leuk...

Neurofeedback- and brain-computer interface (BCI)-based interventions can be implemented using real-time analysis of magnetoencephalographic (MEG) recordings. Head movement during MEG recordings, however, can lead to inaccurate estimates of brain activity, reducing the efficacy of the intervention. Most real-time applications in MEG have utilized analyses that do not correct for head movement. ...

Do task demands change the way we extract information from a stimulus, or only how we use this information for decision making? In order to answer this question for visual word recognition, we used EEG/MEG as well as fMRI to determine the latency ranges and spatial areas in which brain activation to words is modulated by task demands. We presented letter strings in three tasks (lexical decision...

We discuss 3 neurophysiological approaches to study auditory verbal hallucinations (AVH). First, we describe "state" (or symptom capture) studies where periods with and without hallucinations are compared "within" a patient. These studies take 2 forms: passive studies, where brain activity during these states is compared, and probe studies, where brain responses to sounds during these states ar...

The factor-independent Dami/HEL and Meg-01 and factor-dependent Mo7e leukemic cell lines were used as models to investigate JAK/STAT signal transduction pathways in leukemic cell proliferation. Although Dami/HEL and Meg-01 cell proliferation in vitro was independent of and unresponsive to exogenous cytokines including granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-...

It is difficult to perform ictal vs. interictal MEG localization studies. MEG recordings of epileptic seizures are rare and are often accompanied by patient movements. However, during routine MEG recordings of a presurgical patient with epilepsy, a complex partial seizure was recorded with a whole head neuromagnetometer (4D Neuroimaging Magnes WHS2500). During seizure, the patient opened his ey...