نتایج جستجو برای: domain antibodies
تعداد نتایج: 558084 فیلتر نتایج به سال:
Background: In addition to passive immunotherapy using anti-HER2 monoclonal antibodies, active immunotherapy via HER2 targeting is an interesting approach to inducing specific anti-tumor immune responses. We have recently reported the immunogenicity of HER2 subdomains following DNA immunization and HER2 protein boosting. In the present study, we evaluated the immunogenicity of different HER2 ex...
Background: Staphylococcus aureus and Staphylococcus epidermidis are major human pathogens of increasing importance due to the spread of antibiotic resistance. Novel potential targets for therapeutic antibodies are products of staphylococcal genes expressed during human infection. Previously, the secreted and surface-exposed proteins among seroreactive antigens have been discovered. Furthermore...
beta 2 glycoprotein i (β2gpi) is a single chain 50 kda highly glycosylated glycoprotein at an approximate concentration of 4 μm in cells. the abundance of this protein in plasma and its high state of preservation indicate the important role of this protein in mammalian. in addition, β2gpi has a particular structure in the fifth domain, and is categorized as the major antigen recognized by autoa...
Antibodies are the largest class of biotherapeutics. However, in recent years, single-domain antibodies have gained traction due to their smaller size and comparable binding affinity. (Abs) (sdAbs) differ structures sites: most significantly, lack a light chain so just three CDR loops. Given this inherent structural difference, it is important understand whether Abs sdAbs distinguishable how th...
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