نتایج جستجو برای: dosage regimen
تعداد نتایج: 146978 فیلتر نتایج به سال:
ABTRACT Because of the narrow therapeutic range and large inter-patient variability in digoxin’s pharmacokinetics and pharmacodynamics, an appropriate dosage regimen for individuals is needed. However, monitoring and adjusting the optimal individualized dosage regimen requires a knowledge and familiarity of pharmacokinetic equations. The objective of this study was to develop a computer-based p...
BACKGROUND Patients with type 2 diabetes mellitus often take multiple anti-diabetic drugs for a long period. Fixed dose combination (FDC) therapy is expected to improve drug adherence for patients with diabetes. The effect of switching from a loose dose combination (LDC) regimen to an FDC regimen at equivalent dosage on glycemic control has not been evaluated fully. Therefore, we investigated t...
The science of dosage or posology (from Greek posos, how much, and logos, study) is a branch of pharmacology and therapeutics concerned with treatment dosage and dosage regimen. Establishing optimum dosage underpins every clinical development plan for novel therapeutic candidates. Failure to select the adequate drug dose is a leading culprit for regulatory delays or denial of initial applicatio...
High-dose extended-interval dosage (HDED) regimen of aminoglycosides is now considered as the standard dosage strategy in sepsis. Although safety and efficacy of this dosing regimen is well studied, but new experiments show increased the risk of resistance development associated with %T>MIC less than 60% of the dosing interval following extended interval dosing. Moreover, limited information is...
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