AIM To evaluate intraocular biodistribution of fluorescent nanoparticles composed of dexamethasone bound to chitosan after intravitreal administration in rabbit eyes. MATERIAL AND METHODS The chitosan and gelatin based nanoparticles were synthetized using a reverse emulsion-double crosslinking technique (ionic and covalent) and then dexamethasone was bound. Two units of 1% suspension of these...

With many desirable features, such as being more effective and having multiple effects, antiangiogenesis has become one of the promising cancer treatments. The aim of this study was to design and synthesize a new targeted bioresponsive nanosystem with antiangiogenesis properties. The mUPR@Ru(POP) nanosystem was constructed by the polymerization of Ulva lactuca polysaccharide and N-isopropyl acr...

Hybridized decaying oscillations in a nanosystem of two coupled elements—a quantum emitter and a plasmonic nanoantenna—are considered as a classical effect. The circuit model of the nanosystem extends beyond the assumption of inductive or elastic coupling and implies the near-field dipole-dipole interaction. Its results fit those of the previously developed classical model of Rabi splitting, ho...

Efficient strategies for the ultrasensitive imaging of gene expression in living cells are essential in chemistry and cell biology. Here, we report a novel and efficient enzyme-free dual signal amplification strategy for live cell mRNA imaging by using a smart nucleic acid hairpin-based nanosystem. This nanosystem consists of a ZnO nanoparticle core, an interlayer of polydopamine and an outer l...

Currently unsatisfactory treatment of myocardial infarction (MI) is due to the unbridled inflammation and the delayed diagnosis at the early stage. To address these problems, firstly, phosphatidylserine (PS) was used to modulate the phenotypes of macrophages (MΦ) and resolve the early inflammation via binding to PS receptors (PSR) on macrophage surface. Secondly, highly-sensitive magnetic iron ...

Efficient strategies for the ultrasensitive imaging of gene expression in living cells are essential in chemistry and cell biology. Here, we report a novel and efficient enzyme-free dual signal amplification strategy for live cell mRNA imaging by using a smart nucleic acid hairpin-based nanosystem. This nanosystem consists of a ZnO nanoparticle core, an interlayer of polydopamine and an outer l...

The Effect of Niosomal Nanosystem Containing Gentamicin on the Staphylococcus Aureus: A Laboratory Study

Abstract The authors propose an efficient nanosystem based on molecular communication technology. Molecular via diffusion (MCvD) is a promising trend for exchanging biochemical signals between nanotransmitter (NT) and nanoreceiver (NR) in aqueous media over short distances. Nanosystem-based MCvD has recently received lot of attention advanced targeted nanomedicine applications such as drug deli...

Mathematical modeling methods are powerful tools in the design of various types nanosystems and analysis processes taking place them. Note that main tasks mathematical nanoscale systems are: formation nanoelements, interaction individual elements nanosystem, determination structure isolated nanosystem dynamic states, calculation parameters during its with environment, macro nanosystem. With thi...

A novel highly biocompatible nanosystem containing Mg nanoparticles is reported, characterized and tested as a suitable and non-toxic tool for photothermal therapy.