introduction: enterococcus (e) faecalis bacteria adhere to dentine of teeth root canals to form the biofilm. e. faecalis has been shown to be resistant to antibiotics. this in vitro study aimed to investigate the efficacy of vancomycin and doxycycline in inhibiting e. faecalis biofilm formation. materials and methods: a total of 60 extracted human teeth were incubated with e. faecalis (atcc 355...

Objective: In recent years, antibiotics have been used widely in the glob to prevent and treat bacterial diseases. They injected into eggs to eliminate pathogens and prevention of egg transmission of disease, but the adverse effects of drugs have always been a major concern. There is little information available about the safety of tetracycline drugs in the embryonated eggs of the birds. The ob...

To evaluate the effects of antimicrobial and antiinflammatory drugs on oviductal pathology in chronic chlamydial upper genital tract infection, the fallopian tubes of 40 female Macaca nemestrina were inoculated with Chlamydia trachomatis and randomly assigned to treatment with doxycycline (n = 10), doxycycline plus ibuprofen (n = 10), doxycycline plus triamcinolone (n = 10), or placebo (n = 10)...

introduction: the purpose of this ex vivo study was to determine the releasing characteristics and doxycycline dentinal diffusion of ah26 sealer-doxycycline combination from apical 3mm of tooth root and apical foramen . materials & methods: one-hundred and two recently extracted single-rooted human teeth were decoronated and prepared with #3 and #4 gates-glidden drills and rotary mtwo files. sm...

PURPOSE We explored the anti-inflammatory effects of doxycycline in experimental uveitis and the underlying mechanisms. METHODS Rats with endotoxin-induced uveitis (EIU) received doxycycline (1.5 mg/kg) or the control vehicle via intraperitoneal injection. Clinical scores were graded under a slit lamp. Rat peritoneal macrophages were used in vitro to further explore the anti-inflammatory mech...

The aim of the study was to estimate the impact of antibiotic doxycycline on the spring development of the bee colonies, worker bees’ bodies chemical composition, development of hypopharyngeal glands and some physicochemical parameters of honey. The experiment was conducted during the spring stimulating feeding at apiary of Research Center of Stockbreeding and Agriculture, Smolyan, Bulgaria. Tw...

BACKGROUND Inducing mitochondrial dysfunction has been recently demonstrated to be an alternative therapeutic strategy for cancer treatment. Doxycycline is an antibiotic that has been shown to have anti-cancer activities in various cancers by way of targeting mitochondria. In this work, we examined whether doxycycline can be repurposed for glioblastoma treatment. MATERIAL AND METHODS The effect...

OBJECTIVE To compare the efficacy of doxycycline plus methotrexate (MTX) versus MTX alone in the treatment of early seropositive rheumatoid arthritis (RA), and to attempt to differentiate the antibacterial and antimetalloproteinase effects of doxycycline. METHODS Sixty-six patients with seropositive RA of <1 year's duration who had not been previously treated with disease-modifying antirheuma...

Background: Acne vulgaris is the most common disorder of pilosebaceous unit. Systemic antibiotics are known to be effective in its treatment. We performed this investigation to compare the efficacy of azithromycin with doxycycline in the treatment of acne vulgaris. Method: A twelve-week study was performed on 69 patients with moderate facial acne to compare the efficacy of oral azithromyc...