in this article, we show the existence of certain exact sequences with respect to two homology theories, called d-homology and extended d-homology. we present sufficient conditions for the existence of long exact extended d- homology sequence. also we give some illustrative examples.

Enzymes are one of the most important groups of drug targets, and identifying possible ligand-enzyme interactions is of major importance in many drug discovery processes. Novel computational methods have been developed that can apply the information from the increasing number of resolved and available ligand-enzyme complexes to model new unknown interactions and therefore contribute to answer o...

Dentilisin is a surface protease synthesized by the cell wall of Treponema denticola. This protein aids in invasion periodontal tissue causing infection. To identify drug molecules that have better results, homology modeling dentilisin was constructed, and molecular docking performed with oxazole compounds (1-6) taken from previous studies are not yet clinically used. Data shows 1, 2, 3 show in...

Scorpion venom contains different toxins with multiple biological functions. IMe-AGAP is the first Analgesic-Antitumor like Peptide (AGAP) isolated from Iranian scorpion Mesobuthus eupeus. This peptide is similar to AGAP toxin with high analgesic activity, extracted from Chinese scorpion and inhibits NaV1.8 and NaV1.9 voltage-gated sodium channels involved in the ...

The theory of local homology modules was initiated by Matlis in 1974. It is a dual version of the theory of local cohomology modules. Mohammadi and Divaani-Aazar (2012) studied the connection between local homology and Gorenstein flat modules by using Gorenstein flat resolutions. In this paper, we introduce generalized local homology modules for complexes and we give several ways for computing ...

Polygonatum sibiricum, a traditional Chinese medicine with food-medicine homology, contains various bioactive components beneficial to human health, such as polysaccharides, saponins, anthraquinones, alkaloids, cardenolides, lignans, vitamins, etc. sibiricum granules are patent prepared from the dried rhizomes of sibiricum. They exhibit extensive pharmacological activities, including nourishing...

Scorpion venom contains different toxins with multiple biological functions. IMe-AGAP is the first Analgesic-Antitumor like Peptide (AGAP) isolated from Iranian scorpion Mesobuthus eupeus. This peptide is similar to AGAP toxin with high analgesic activity, extracted from Chinese scorpion and inhibits NaV1.8 and NaV1.9 voltage-gated sodium channels involved in the ...

Understanding of drug binding to the human biogenic amine transporters (BATs) is essential to explain the mechanism of action of these pharmaceuticals but more importantly to be able to develop new and improved compounds to be used in the treatment of depression or drug addiction. Until recently no high resolution structure was available of the BATs and homology modeling was a necessity. Variou...

We investigate the relative cohomology and relative homology theories of $F$-Gorenstein modules, consider the relations between classical and $F$-Gorenstein (co)homology theories.

background : the aim of this study was to generate in silico 3d-structure of the envelope protein of ahfv using homology modeling method to further predict its conformational epitopes and help other studies to investigate its structural features using the model. methods : a 3d-structure prediction was developed for the envelope protein of alkhumra haemorrhagic fever virus (ahfv), an emerging ti...