The liver is the largest internal organ in the human body that is responsible for more than 500 vital functions, including biosynthesis of major plasma proteins, immunity against infectious pathogens, balancing energy metabolism and xenobiotics biotransformation (1). One of the main functions of the liver is an important role in drug metabolism (2). Since developing new drug compounds into mark...

Drug Screening In article number 2207194, Mengsu Yang and co-workers design a high throughput microfluidic chip that could achieve multi-function drug screening against collective migration of cancer cells under confined environment. Using this device, three new compounds significantly inhibit are found: MA-5, SB-705498 diphenyleneiodonium chloride (DPI). These target mitochondria, actin polyme...