Nigini Oliveira Computer Science & Engineering, DUB group University of Washington [email protected] Katharina Reinecke Computer Science & Engineering, DUB group University of Washington [email protected] Eunice Jun Computer Science & Engineering, DUB group University of Washington [email protected] Trevor Croxson Computer Science & Engineering, DUB group University of Was...

BRCC36 is a Zn(2+)-dependent deubiquitinating enzyme (DUB) that hydrolyzes lysine-63-linked ubiquitin chains as part of distinct macromolecular complexes that participate in either interferon signaling or DNA-damage recognition. The MPN(+) domain protein BRCC36 associates with pseudo DUB MPN(-) proteins KIAA0157 or Abraxas, which are essential for BRCC36 enzymatic activity. To understand the ba...

Coronaviruses encode multifunctional proteins that are critical for viral replication and for blocking the innate immune response to viral infection. One such multifunctional domain is the coronavirus papain-like protease (PLP), which processes the viral replicase polyprotein, has deubiquitinating (DUB) activity, and antagonizes the induction of type I interferon (IFN). Here we characterized th...

Background: The term dysfunctional uterine bleeding(DUB) refers to any abnormal bleeding from the uterus, unassociated with tumour, inflammation and pregnancy. The histological diagnosis of DUB is very essential for adequate management especially in perimenopausal and postmenopausal females. The present study was undertaken with the aim of evaluating DUB in various age groups, carry out histopa...

This article takes its name and inspiration from Mad Professor’s album A Caribbean Taste of Technology in response to the theme of this Technosphere issue. This makes a good place to start a discussion of creolization and technology – the dub reggae tracks of this album produced British producer Mad Professor and released in 1985, https://www.youtube.com/watch?v=ewDTHfJqLwI So what I present he...

Cytokines, such as interleukin-2 (IL-2), activate intracellular signaling pathways via rapid tyrosine phosphorylation of their receptors, resulting in the activation of many genes involved in cell growth and survival. The deubiquitinating enzyme DUB-2 is induced in response to IL-2 but as yet its function has not been determined. The results of this study show that DUB-2 is expressed in human T...

The aim of this study was to investigate the relation between Celiac disease (CD) and unexplained dysfunctional uterine bleeding (DUB) in celiac women. The celiac patients were selected from women who were referred to celiac department. Controls were selected from those women without any signs of celiac disease and matched with age. Meanwhile, a trained physician was ready to explain the study,...

OBJECTIVE Bipolar disorder (BD) is often left untreated for long periods, and this delay in treatment correlates with unfavorable prognosis. The present study sought to assess the magnitude of duration of untreated bipolar disorder (DUB) in Brazil. We hypothesized that DUB would be longer in Brazil than in developed countries, and would be associated with poor clinical outcomes. METHODS One h...

Downlo ent evidence suggests that several deubiquitinases (DUB) are overexpressed or activated in tumor cells any contribute to the transformed phenotype. Agents with DUB inhibitory activity may therefore have eutic value. In this study, we describe the mechanism of action of WP1130, a small molecule derived compound with Janus-activated kinase 2 (JAK2) kinase inhibitory activity. WP1130 induce...