نتایج جستجو برای: dupuytren
تعداد نتایج: 472 فیلتر نتایج به سال:
Dupuytren's disease causes disability because of the development of finger flexion deformities, with distinct nodule and cord formation. This results in physical shortening of the diseased fascial tissue through a combination of cell-mediated contraction and matrix remodeling. It is this fixed tissue fabric shortening that prevents finger extension. In this experimental study, the relative cont...
Dear Sir, Dupuytren nodules form early in the course of the disease and usually precede the development of joint contracture. These nodules can present with or without pain and can be multiple in numbers (Fig. 1). Currently, although nodules may be symptomatic with pain, no specific intervention is recommended. Treatment is generally delayed until joint contracture develops. There are numerous ...
PURPOSE It is thought that local ischemia and oxygen radicals are responsible for fibroblast-to-myofibroblast cell transformation and proliferation. We hypothesized that hypoxia could differentially activate the contractility of fibroblasts from normal human palmar fascia and from fibroblasts-myofibroblasts of Dupuytren cords. METHODS Normal palmar fascia from 5 patients with carpal tunnel sy...
Dupuytren ́s disease, a fibromatosis of the connective tissue in the palm, is a common complex disease with a strong genetic component. Up to date nine genetic loci have been found to be associated with the disease. Six of these loci contain genes that code for Wnt signalling proteins. In spite of this striking first insight into the genetic factors in Dupuytren ́s disease, much of the inherited ...
BACKGROUND To determine the safety and efficacy of collagenase clostridium histolyticum (CCH) injection for the treatment of palmar Dupuytren disease nodules. METHODS In this 8-week, double-blind trial, palpable palmar nodules on one hand of adults with Dupuytren disease were selected for treatment. Patients were randomly assigned using an interactive web response system to receive a dose of ...
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