The present study was designed to investigate whether absolute work rate (WR) affects Phase I pulmonary oxygen uptake (Vo(2)(p)) duration during moderate-intensity (Mod) exercise and to compare two methods for estimating Phase I Vo(2)(p) duration (P(I-Dur)). Fourteen males (24 ± 5 yr) each completed 4-8 repetitions of Mod transitions from 20 W to 50, 70, 90, 110, and 130 W. P(I-Dur) was identif...

In this article the authors present population-level prevalence rates for 61 specific drug-related problems occurring in three State Medicaid programs (Maryland, Iowa, and Washington) from 1989 through 1996 and a fourth (Georgia) from 1994 through 1996. The findings represent the first application of a consistent drug utilization review (DUR) screener program to Medicaid data across States. The...

As policymakers debate adding a prescription drug benefit to Medicare, they must also seek ways to promote cost-effective use of drugs and minimize inappropriate prescribing. For more than a decade, all state Medicaid agencies and most private insurers have used computerized drug utilization review (DUR) programs to prevent or rectify potential prescribing errors. DUR can be retrospective, in w...

In Saccharomyces cerevisiae, the degradation of urea to carbon dioxide and ammonia is catalyzed by urea carboxylase and allophanate hydrolase. The loci coding for these enzymes (dur1 and dur2) are very tightly linked on the right arm of chromosome II between pet11 and met8. Pleiotropic mutations that fail to complement mutations in either of the dur loci were found to be predominantly located i...

A good correlation should be obtained between data derived from in vitro dissolution and bioavailability studies on drug delivery systems if bioavailability parameters are to be reliably predicted from the in vitro dissolution variables. This study compares the in vivo absorption with the in vitro dissolution profiles into various dissolution media of a novel controlled release theophylline cap...

A previous paper (Mahler, M. 1978. J. Gen. Physiol. 71:559-580) describes the t ime-course o f the suprabasal rate of oxygen consumption (AQo~) in the sartorius muscle o fR . p/p/ens after isometric tetani of 0.1-1.0 s at 20~ To test whether these were the responses to impulse changes in the rate of ATP hydrolysis, we compared the total suprabasal oxygen consumption dur ing recovery (A[O~]) wit...

A previous paper (Mahler, M. 1978. J. Gen. Physiol. 71:559-580) describes the t ime-course o f the suprabasal rate of oxygen consumption (AQo~) in the sartorius muscle o fR . p/p/ens after isometric tetani of 0.1-1.0 s at 20~ To test whether these were the responses to impulse changes in the rate of ATP hydrolysis, we compared the total suprabasal oxygen consumption dur ing recovery (A[O~]) wit...

BACKGROUND & OBJECTIVES Information available on drug consumption is inadequate in most low and middle income countries. This systematic review was conducted to analyse published work on drug utilization research/studies (DUR) in the SEARO region of WHO for study objectives, methodology, results and recommendations and to identify the need for improving DUR and the use of the ATC/DDD system. ...

Two nitro-substituted 1,4-distyrylbenzene-like compounds have been investigated using stationary and time-resolved (ns/fs) spectrometric techniques as a function of solvent polarity. In the two compounds the central benzene ring is substituted with a p-nitrostyryl group at one side while, at the other side, compound 1 (asymmetric) bears a pyrid-4-ylethenyl group and compound 2 (symmetric) anoth...

In this study, three enzyme hydrolysate termed Dur-A, Dur-B, and Dur-C, were produced from Durvillaea antarctica biomass using viscozyme, cellulase, α-amylase, respectively. exhibited fucose-containing sulfated polysaccharide chemical composition determination characterization by FTIR analyses. addition, had high extraction yields low molecular weights. All extracts determined to have antioxida...