BACKGROUND Proton pump inhibitors (PPIs) are widely applied for acid related disorders, and possess pleiotropic biological functions. The effect of PPIs on the gastric mucosa, neutrophil and Helicobacter pylori (H. pylori) infiltration and glandular atrophy has not been well investigated, particularly the duration of the effects of PPIs. OBJECTIVES To investigate the effects of PPIs on neutro...

abstract objective: diabetic peripheral neuropathy is the main risk factor of diabetic foot ulcer and its early diagnosis is important to prevent limb amputation. we assessed the prevalence of peripheral neuropathy in diabetic patients. materials and methods: this cross-sectional study was performed on 352 randomly selected diabetic patients using a standardized questionnaire including age, gen...

trade relationships built through production chains appear to be lasting due to relation-specific nature of the transactions, compared with the usual transactions of goods sold on the open market. this paper aims to verify such stability of international production networks at the global level, with special emphasis on intra-east asian trade. a series of survival analyses provide an evidence su...

background: betel nut and betel quid chewing are from major etiological factor for oral cancer. they also increase the risk of systemic diseases such as asthma, diabetes mellitus, metabolic syndrome, myocardial infarction, hypertension, and other cardiovascular diseases. methods: sixty three patients of oral cancer in our institution during jan. 2007 to may 2011 were included in our study. this...

A hyperproductive mucosal state in gluten-sensitive enteropathy has been proposed on the basis of an elevated mitotic index, but this parameter is dependent on the mitotic duration when used as an index of proliferative status. The mitotic duration was therefore measured in two control patients with normal villous mucosae and in two patients with the flat avillous mucosa of untreated gluten-sen...

today bleach and detergents are being frequently used and some people use their mixture for more cleaning. because of chemical interaction of bleach and detergent, chlorine gas was released and thereby it could be dangerous for human health. this study examined the effects of exposed toxic mixture of bleach and detergent on the mucosa layer and lamina mucosa conjunctiva in the mice. in this stu...

Aim: Betel chewer’s mucosa, although not considered as a potentially malignant lesion, has been suggested to be a precursor of oral submucous fibrosis (OSMF). Thus a study was undertaken to asses various quid chewing patterns in patients with chewer’s mucosa and to evaluate possible association between chewer’s mucosa and a particular quid usage pattern. Materials and methods: The study was don...

   The objective of the present investigation was to develop and evaluate a contraceptive vagino-adhesive propranolol hydrochloride gel. To achieve this, various mucoadhesive polymers including guar gum (1-4% w/w), sodium alginate (4-7% w/w), xanthan gum (2-5% w/w ), HPMC 4000 (3-5% w/w), Na CMC (4-7% w/w), carbomer 934 and carbomer 940 both in the range of 0.5-2.0% w/w, were dispersed in an aq...