We analyze the decomposition of recently constructed unfaithful spinor representations of K(E10) under its SO(9)×SO(9), and SO(9)×SO(2) subgroups, respectively, where K(E10) is the ‘maximal compact’ subgroup of the hyperbolic Kac–Moody group E10. We show that under these decompositions, respectively, one and the same K(E10) spinor gives rise to both the fermionic fields of IIA supergravity, and...

v-E10, a caspase recruitment domain (CARD)-containing gene product of equine herpesvirus 2, is the viral homologue of the bcl-10 protein whose gene was found to be translocated in mucosa-associated lymphoid tissue (MALT) lymphomas. v-E10 efficiently activates the c-jun NH(2)-terminal kinase (JNK), p38 stress kinase, and the nuclear factor (NF)-kappaB transcriptional pathway and interacts with i...

Frontotemporal dementia with parkinsonism, chromosome 17 type (FTDP-17) is caused by mutations in the tau gene, and the signature lesions of FTDP-17 are filamentous tau inclusions. Tau mutations may be pathogenic either by altering protein function or gene regulation. Here we show that missense, silent, and intronic tau mutations can increase or decrease splicing of tau exon 10 (E10) by acting ...

Chromatin modifications are critical for the establishment and maintenance of differentiation programs. G9a, the enzyme responsible for histone H3 lysine 9 dimethylation in mammalian euchromatin, exists as two isoforms with differential inclusion of exon 10 (E10) through alternative splicing. We find that the G9a methyltransferase is required for differentiation of the mouse neuronal cell line ...

We continue the study of the one-dimensional E10 coset model (massless spinning particle motion on E10/K(E10)) whose dynamics at low levels is known to coincide with the equations of motion of maximal supergravity theories in appropriate truncations. We show that the coset dynamics (truncated at levels l ≤ 3) can be consistently restricted by requiring the vanishing of a set of constraints whic...

Frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) is caused by mutations in the MAPT gene, encoding the tau protein that accumulates in intraneuronal lesions in a number of neurodegenerative diseases. Several FTDP-17 mutations affect alternative splicing and result in excess exon 10 (E10) inclusion in tau mRNA. RNA reprogramming using spliceosome-mediated RNA trans-spl...

It has been conjectured that the classical dynamics of M theory is equivalent to a null geodesic motion in the infinite-dimensional coset space E10/K(E10), where K(E10) is the maximal compact subgroup of the hyperbolic Kac-Moody group E10. We here provide further evidence for this conjecture by showing that the leading higher order corrections, quartic in the curvature and related three-form de...

As far as we know, there is no decoding algorithm of any binary self-dual [40, 20, 8] code except for the syndrome decoding applied to the code directly. This syndrome decoding for a binary self-dual [40, 20, 8] code is not efficient in the sense that it cannot be done by hand due to a large syndrome table. The purpose of this paper is to give two new efficient decoding algorithms for an extrem...