Good outcomes have been reported after both open and percutaneous surgery to release trigger thumb. This study evaluated short-term and long-term outcomes after treatment of trigger thumb with open or percutaneous release. A total of 126 trigger thumbs in 107 patients were reviewed from 2009 to 2012. Short-term (3 months) and long-term results (2 years) and complications of open release (58 dig...

OBJECTIVES: Barrett’s esophagus (BE) is the only known precursor to esophageal adenocarcinoma. Data examining the association of aspirin with the onset of BE, particularly for women, are scant and conflicting. METHODS: We leveraged data from 121,700 women enrolled in the Nurses’ Health Study, a large prospective cohort study, who biennially provided detailed information regarding endoscopy and ...

Endo-N-acetyl-β-D-glucosaminidases (ENGases) hydrolyze the glycosidic linkage between the two N-acetylglucosamine units that make up the chitobiose core of N-glycans. The endo-N-acetyl-β-D-glucosaminidases classified into glycoside hydrolase family 18 are small, bacterial proteins with different substrate specificities. Recently two eukaryotic family 18 deglycosylating enzymes have been identif...

Abstract Introduction Baclofen is a gamma-aminobutyric acid-B agonist that targets neurons in the spinal cord and brain. It has skeletal muscle-relaxant properties FDA approved to treat spasticity from injury (SCI), multiple sclerosis, or traumatic brain injury. Off label use includes treatment of alcohol disorder, hiccups, muscle spasms. A rare respiratory side effect baclofen apnea, with repo...

Abstract Introduction Central sleep apnea (CSA) is a rare form of disordered breathing with repeated apneic episodes absence associated respiratory effort. CSA due to medication well described in literature opiate therapy. Baclofen which gamma-aminobutyric acid-B agonist muscle relaxant properties has been implicated CSA. We present case likely chronic baclofen use. Patient underwent polysomnog...

Background: In the NCI-MATCH trial, pts receive agents based on genetic alterations in their tumors. sub-protocol EAY131-Z1K, with AKT1 E17K mutant metastatic tumors received pan-AKT inhibitor ipatasertib. Methods: Pts ipatasertib orally once daily a 28-day cycle until progression or unacceptable toxicity. well-controlled diabetes were eligible, unless baseline fasting glucose >160 mg/dL, Hemog...

TOPIC: Lung Pathology TYPE: Medical Student/Resident Case Reports INTRODUCTION: Intrapulmonary teratomas (IPT) are a rare extra-gonadal manifestation of and challenging diagnosis to make. We present patient with IPT presenting hemoptysis. CASE PRESENTATION: A 49-year-old man presented intermittent non-massive hemoptysis throughout the previous year. Labs were normal exception normocytic anemia ...

Sir, Clinical experience has shown that oropharyngeal carriage of methicillin-resistant Staphylococcus aureus (MRSA) can be difficult to eradicate.1 Oral carriage of MRSA may serve as a reservoir for colonization of other body sites, or cross-infection to other patients or healthcare workers.2 Eradication of throat carriage of MRSA has been achieved using topical chlorhexidine (0.2%), in additi...

<div id="contentsContainer" class="style-scope qowt-page"><div id="contents" qowt-page"><p id="E129" class="x-scope qowt-word-para-4"><strong><span id="E130" class="qowt-font2-Arial">ABSTRAK </span></strong></p><p id="E131" qowt-word-para-5"><span id="E132" class="qowt-font2-Arial"><strong>Latar Belakang:</strong> </span...