The effect of grain refinement of commercial purity titanium by equal channel angular pressing (ECAP) on its mechanical performance and bone tissue regeneration is reported. In vivo studies conducted on New Zealand white rabbits did not show an enhancement of biocompatibility of ECAP-modified titanium found earlier by in vitro testing. However, the observed combination of outstanding mechanical...

One hundred and forty-seven adult recipients of the Nucleus 24 cochlear implant system, from 13 different European countries, were tested using neural response telemetry to measure the electrically evoked compound action potential (ECAP), according to a standardised postoperative measurement procedure. Recordings were obtained in 96% of these subjects with this standardised procedure. The group...

A Fe-20.1Mn-1.23Si-1.72Al-0.5C TWIP steel with ultra-fine grain structure was successfully processed through Equal Channel Angular Pressing (ECAP) at warm temperature up to four passes following the BC route. The microstructure evolution was characterized by Electron Back Scattered Diffraction (EBSD) to obtain the grain maps, which revealed an obvious reduction of grain size, as well as a decre...

Partial loss and subsequent recovery of cochlear implant function in the first few weeks following cochlear implant surgery has been observed in previous studies using psychophysical detection thresholds. In the current study, we explored this putative manifestation of insertion trauma using objective functional measures: electrically-evoked compound action potential (ECAP) amplitude-growth fun...

The effect of surface electrode positioning on the evoked compound action potential (ECAP) was studied during inhalation anaesthesia without neuromuscular blockade. The ECAP of five full-term infants (aged 2-20 weeks) and five children (age 1-10 yr) was recorded with a neuromuscular relaxation monitor (Relaxograph, Datex) after supramaximal ulnar nerve stimulation. The five recording electrode ...

A spray-cast Al-7034 alloy was processed by equal-channel angular pressing (ECAP) to a total of 8 passes at 473 K and the pressed samples were examined using transmission electron microscopy, differential scanning calorimetry and electron back-scatter diffraction. It is shown that the grain size of the alloy is reduced to ~0.3 μm by ECAP and the high pressures associated with ECAP lead to a fra...

Closed-loop deep brain stimulation (DBS) systems could provide automatic adjustment of stimulation parameters and improve outcomes in the treatment of Parkinson's disease and essential tremor. The evoked compound action potential (ECAP), generated by activated neurons near the DBS electrode, may provide a suitable feedback control signal for closed-loop DBS. The objectives of this work were to ...

49 Closed-loop deep brain stimulation (DBS) systems could provide automatic adjustment of stimulation 50 parameters and improve outcomes in the treatment of Parkinson's disease and essential tremor. The 51 evoked compound action potential (ECAP), generated by activated neurons near the DBS electrode, may 52 provide a suitable feedback control signal for closed-loop DBS. The objectives of this w...

In this study we aim to resolve the contributions of facilitation and refractoriness at very short pulse intervals. Measurements of the refractory properties of the electrically evoked compound action potential (ECAP) of the auditory nerve in cochlear implant (CI) users at inter pulse intervals below 300 μs are influenced by facilitation and recovery effects. ECAPs were recorded using masker pu...

This study investigated the effects of acoustic noise on the auditory nerve compound action potentials in response to electric pulse trains. Subjects were adult guinea pigs, implanted with a minimally invasive electrode to preserve acoustic sensitivity. Electrically evoked compound action potentials (ECAP) were recorded from the auditory nerve trunk in response to electric pulse trains both dur...