Within the realm of medicinal chemistry, synthesis plays a pivotal role in any drug research and development endeavor. The ability to design elegant and economical synthetic routes is often a major factor for making a drug a commercial winner. Retrosynthetic analysis/ Synthon disconnection approach, introduced and advanced by Prof. E. J. Corey of Harvard University has served as a powerful driv...

Because vanadium (V) is easily reduced to a cationic form within plant cells, data from resin-extraction of soil were analysed for evidence 5 of interactions between V and the resin-extractable concentrations of magnesium (Mg) and calcium (Ca) on soybean seed yield. Three varieties, 9091, 9061 and 704, were grown over a 3-year period in a corn± soybean±wheat rotation. Surface soil samples (0±15...

in order to study the correlation between morphophenological and quantitative traits with yield and to determine the most important traits for yield, 600 ecotypes of mung bean were evaluated in normal and limited irrigation conditions through augmented design. computation of correlation coefficients showed that in two conditions, number of pods per plant, harvest index and biological yield had ...

A rapid yield estimation methodology that aids the analog circuit designer in making design trade-offs that improve yield is presented. This methodology is based on using hierarchical evaluation of analysis equations, rather than simulation, to predict circuit performance. The new analog rapid yield estimation (ARYE) method has been used to predict the yield of two-stage op amps, and has been i...

A metal-free, TBHP-promoted economical route is developed via the sp(2) C-H bond functionalization strategy for the synthesis of indenoquinolinones, 4-azafluorenones and fluorenones. Reactions provided excellent yield of the products under mild conditions. We have successfully synthesized 11H-indeno[1,2-b]quinolin-11-one, an antibacterial agent, in excellent yields.

The reaction of primary aromatic amines with aryl aldehydes is found to be catalyzed by lemon juice as natural acid under solvent-free conditions to give the corresponding Schiff bases in good yields. This eco-friendly reaction has many advantages like economical, environmental, mild reaction conditions and simple work-up with high product yield.

Microwave-enhanced, highly efficient protocols for the synthesis of synthetically and biologically important 2,3,6-trisubstituted pyridazine architectures have been developed by sequential amination/Suzuki coupling/alkylation reactions. This powerful strategy is an economical and highly chemoselective protocol for the synthesis of diversified pyridazines. The total synthesis of gabazine (SR-955...