Metastasis is the main cause of mortality in individuals with cancer. Thus, the identification of genes that are important for this process is essential. We used Affymetrix gene expression profiling of human colorectal adenocarcinomas to identify genes whose expression characterizes metastatic tumors. Following laser capture microdissection we isolated RNA from metastasizing and non-metastasizi...

Cell-surface F1F0-ATP synthase was involved in the cell signaling mediating various biological functions. Recently, we found that cell-surface F1F0-ATP synthase plays a role on intracellular triacylglycerol accumulation in adipocytes, and yet, the underlying mechanisms remained largely unknown. In this study, we investigated the role of extracellular ATP on the intracellular triacylglycerol acc...

Although molecular components of the circadian clock are known, mechanisms that transmit signals from the clock and produce rhythmic behavior are poorly understood. We find that the microRNA miR-279 regulates the JAK/STAT pathway to drive rest:activity rhythms in Drosophila. Overexpression of microRNA miR-279 or miR-279 deletion attenuates rest:activity rhythms. Oscillations of the clock protei...

These are notes in progress a graduate course in mathematics. Any suggestions or comments are welcome and can be sent to [email protected].

This annotated bibliography is a complement to a set of course notes for CS 279, System Support for Scientific Computation, taught in Spring 2001 by W. Kahan at UC Berkeley. It is meant to be representative, not comprehensive, and includes pointers to survey works and online bibliographies which cover the literature in various areas in more depth. In the hope of making the bilbiography simpler ...

BACKGROUND The erythroblastosis virus E26 transforming sequences (ETS) family of transcription factors consists of a highly conserved group of genes that play important roles in cellular proliferation, differentiation, migration and invasion. Chromosomal translocations fusing ETS factors to promoters of androgen responsive genes have been found in prostate cancers, including the most clinically...

BACKGROUND Genomic rearrangements involving the ETS family of transcription factors occur in 40-70% of prostate cancer cases. ERG and ETV1 are the most common ETS members observed in these genetic alterations. The high prevalence of these rearrangements and their biological significance represents a novel therapeutic target for the treatment of prostate cancer. METHODS AND FINDINGS We recentl...

While most miRNA knockouts exhibit only subtle defects, a handful of miRNAs are profoundly required for development or physiology. A particularly compelling locus is Drosophila mir-279, which was reported as essential to restrict the emergence of CO2-sensing neurons, to maintain circadian rhythm, and to regulate ovarian border cells. The mir-996 locus is located near mir-279 and bears a similar...