Three simple and rapid spectrophotometric methods were developed for detection and trace determination of benzophenone (the main impurity) in phenytoin bulk powder and pharmaceutical formulations. The first method, zero-crossing first derivative spectrophotometry, depends on measuring the first derivative trough values at 257.6 nm for benzophenone. The second method, zero-crossing third derivat...

Articles about the development of derivative spectrophotometric methods and analytical applications of derivative spectrophotometry (DS) published in the last nine years (since 1994) are reviewed.

in this study, different derivative spectrophotometric methods are proposed for the simultaneous determination of chlorpheniramine maleate (cp), phenylephrine hcl (pe) and phenylpropanolamine hcl (pp) in their ternary mixtures and in pharmaceutical dosage forms. spectra of single component and ternary mixtures of various concentrations and combinations from zero- to fourth-derivation were obtai...

In this study, zero-, first-, secondand third-order derivative spectrophotometric methods were developed for quantitave determination of atenolol in pharmaceutical preparation. In zero order spectrophotometry, absorbance values were measured at 276 nm in zero order spectra of solution of atenolol in methanol in the range of 245-310 nm. In first derivative spectrophotometry, absorbance values we...

Iron is quantitatively retained on an adsorbent made by coprecipitation of 1,2-dihydroxybenzene-3,5-disulfonic acid (Tiron) and tetradecyldimethylbenzylammonium choride (TDBA) an microcrystalline naphthalene as a slurry or packed in a column, in the pH range 6.0-9.0 from a large volumes of aqueous solutions (up to 200 ml on microcrystalline naphthalene and up to 500 ml of aqueous solutions ...

Theoretical aspects, instrumental devices and analytical applications of derivative ultraviolet-visible region absorption spectrophotometry are reviewed.

Two simple and rapid spectrophotometric methods were developed for the determination of two binary mixtures: moxifloxacin hydrochloride (MFH) with ketorolac tromethamine (KTM) and ciprofloxacin hydrochloride (CFH) with dexamethasone sodium phosphate (DSP). The first method, zero-crossing derivative spectrophotometry, depends on measuring the second derivative peak and trough values at 304 nm an...

The present work aims to develop a spectrophotometric method for simultaneous estimation of melatonin and Vitamin C in combined dosage form. Absorbance of melatonin and Vitamin C were measured at the absorbance maximum (λ max) at 278 and 256 nm, respectively. The coefficient of correlation for melatonin at 278 nm and Vitamin C at 256 nm is 0.9986 and 0.9968, respectively. A linear relation betw...

tropicamide is an antimuscarinic agent used as eye drops for refractive examinations. the aim of this study was to develop a simple and suitable analytical method for determination of tropicamide in eye drops in the presence of excipients. a zero-crossing third and fourth derivative spectrophotometric method was described for determination of tropicamide in eye drops. the measurements were carr...

Amygdalin is a cyanogenic glucoside found in apricot kernels. To facilitate the exploitation and use of wild apricot resources, it is necessary to be able to rapidly and efficiently determine the amygdalin levels within their kernels. To do so, this paper compares two methods, one based on second-derivative UV spectrophotometry and the other on highperformance reversed-phase liquid chromatograp...