Ejaculation is controlled by a spinal ejaculation generator located in the lumbosacral spinal cord, consisting in male rats of lumbar spinothalamic (LSt) cells and their inter-spinal projections to autonomic and motor centers. LSt cells co-express several neuropeptides, including gastrin releasing peptide (GRP) and enkephalin. We previously demonstrated in rats that GRP regulates ejaculation by...

A Thoroughbred stallion with erectile dysfunction following paraphimosis was managed to allow consistent ejaculation. Ejaculation was elicited in this stallion by applying manual stimulation to the base of the penis. This technique allowed consistent ejaculation, and the stallion was able to return to natural service. Historically, stallions with this degree of penile dysfunction have been cons...

Male sexual response comprises four phases: excitement, including erection; plateau; ejaculation, usually accompanied by orgasm; and resolution. Ejaculation is a complex sexual response involving a sequential process consisting of two phases: emission and expulsion. Ejaculation, which is basically a spinal reflex, requires a tight coordination between sympathetic, parasympathetic, and somatic e...

The definition of premature ejaculation has not yet been agreed upon in the international community, which can be divided into primary premature ejaculation, secondary premature ejaculation, variability premature ejaculation and premature ejaculation likely erectile dysfunction. The diagnosis can be carried out based on the patient’s medical history, the sexual evaluation table and the neurolog...

Introduction. Ejaculatory/orgasmic disorders are common male sexual dysfunctions, and include premature ejaculation (PE), inhibited ejaculation, anejaculation, retrograde ejaculation, and anorgasmia. Aim. To provide recommendations and guidelines concerning current state-of-the-art knowledge for management of ejaculation/orgasmic disorders in men. Methods. An international consultation in colla...

INTRODUCTION Selective serotonin reuptake inhibitors (SSRIs) differ in the severity of induced ejaculation delay. Various studies indicate that oxytocin is involved in sexual behavior. AIM To review and evaluate the involvement of oxytocin in SSRI-induced ejaculation delay. MAIN OUTCOME MEASURES Oxytocine release, 5-hydroxytryptamine (5-HT) neurotransmission, and desensitization of 5-HT(1A)...

OBJECTIVES: To discuss a concept about the current definition and treatment of premature ejaculation. METHODS: A detailed review was performed on the current definition and treatment of premature ejaculation. RESULTS: Several definitions were found, however a consensus on how to define premature ejaculation is lacking. In addition, there are several treatments: daily, on demand and topical agen...

The definition of premature ejaculation has not yet been agreed upon in the international community, which can be divided into primary premature ejaculation, secondary premature ejaculation, variability premature ejaculation and premature ejaculation likely erectile dysfunction. The diagnosis can be carried out based on the patient’s medical history, the sexual evaluation table and the neurolog...

The objectives of this investigation were to determine the degree of correspondence in the sexual performance of twin male sheep and to compare the sexual performance of ram lambs born co-twin to another male (M-M), co-twin to a female (M-F) and as single (S) offspring. Individual ram lambs (N=117), including 13 M-M twin sets, were exposed to four estrous ewes for 30 min at 7-day intervals over...