introduction: neuroinflammation may play as an important risk factor in progressive degeneration of dopaminergic cells. antioxidants have protective effects against free radicalsinduced neural damage in parkinson’s disease (pd). in the present study, we examined the effects of ellagic acid (ea) on locomotion and neuroinflammatory biomarkers in a rat model of pd induced by 6-hydroxidopamine (6-o...

The effects of four ellagitannin metabolites (M1-M4) and ellagic acid on immunoglobulin E-mediated allergic responses in rat basophilic leukemia-2H3 cells were investigated. M1-M4 inhibited the antigen-induced degranulation and secretion of interleukin-4 and tumor necrosis factor-α, but ellagic acid only slightly did so under the same experimental conditions. M1 inhibited the activation of the ...

Background & Aim: Free radicals are produced in ischemic processes. Nerve damage caused by free radicals may play a role in neurological diseases and antioxidants are protective activity. Ellagic acid is a polyphenol compound with antioxidant properties which is found in fruits like pomegranate, blackberry, and all types of mulberry. This study aimed to evaluate the effect of 14 days of oral ad...

background & aim: free radicals are produced in ischemic processes. nerve damage caused by free radicals may play a role in neurological diseases and antioxidants are protective activity. ellagic acid is a polyphenol compound with antioxidant properties which is found in fruits like pomegranate, blackberry, and all types of mulberry. this study aimed to evaluate the effect of 14 days of ora...

Purpose: To investigate if ellagic acid exerts neuroprotective effects in hypoxic-ischemic (HI) brain injury by inhibiting apoptosis and inflammatory responses. Methods: Separate groups of rat pups from post-natal day 4 (D4) were administered with ellagic acid (10, 20 or 40 mg/kg body weight) orally till post-natal day 10 (D10). On D10, the rats were subjected to HI brain injury. Following HI i...

Background & Aim: Free radicals are produced in ischemic processes. Nerve damage caused by free radicals may play a role in neurological diseases and antioxidants are protective activity. Ellagic acid is a polyphenol compound with antioxidant properties which is found in fruits like pomegranate, blackberry, and all types of mulberry. This study aimed to evaluate the effect of 14 days of oral ad...

In an effort to characterize active principles for diabetic complication from medicinal mushroom, aldose reductase inhibitors were isolated from the fruiting body of Phellinus linteus and identified as hispidin (5), phelligridimer A (6), davallialactone (7), methyldavallialactone (8), hypholomine B (9), interfungins A (10), and inoscavin A (11), together with protocatechuic acid (1), protocatec...

Ellagic acid is a naturally occurring plant phenol which has been shown to reduce the incidence of a number of carcinogen-induced tumors including methylbenzylnitrosamine (MBN)-induced esophageal carcinoma in the rat. The postulated mechanism of MBN-induced esophageal carcinogenesis is through oxidation of MBN to form benzaldehyde and an activated metabolite which methylates DNA forming a varie...

In the paper entitled " A comparative study for the evaluation of two doses of ellagic acid on hepatic drug metabolizing and antioxidant enzymes in the rat " , there was an error in Figure 4, and here we provide the right form of Figure 4.

objective(s):parkinson's disease (pd) is known for motor impairments. but often, there are non-motor symptoms such as cognitive deficiency and pain misperception, owing to possible role of nigrostriatal pathway. antioxidants have protective effect on free radical-induced neuronal damage in pd. to further address, we examined the effects of ellagic acid (ea) in a rat model of pd induced by ...