We report on the case of a 40-year-old male who was admitted to the clinic with a large ulcer on his left buttock, 3 days after an intramuscular benzathine penicillin injection. The patient was diagnosed with Nicolau syndrome, a rare vascular complication in which a lesion develops after intramuscular injection. Symptoms are intense pain at the injection site, erythema, and livedoid dermatitis,...

Nicolau syndrome (Embolia cutis medicamentosa) is a rare complication following parenteral administration of a drug. It has been reported in association with intramuscular, subcutaneous, intravenous and intra-articular injections. However, Nicolau syndrome following intramatricial injection has not been described to the best of our knowledge. We report the case of an 18-year-old male who develo...

267 We read with interest the article by Kim and colleagues [1] entitled “Nicolau’s syndrome after intramuscular injection: 3 cases.” Recently, we published a case report in The Journal of Dermatology about embolia cutis medicamentosa [2]. Herewith, we highlight the lethal potential and the possible serious complications of this syndrome by reporting a case of complicated life-threatening Nicol...

we report a case of nicolau syndrome in a 15 months old girl following of an intramuscular injection of penicillin 6.3.3 in her left buttock. this case is unique because she developed compartment syndrome in her left calf far from her injection site. her toe’s tips gangrened in the course of her ailment. we hypothesized that the compartment syndrome might be produced by a probable intra-arteria...

INTRODUCTION Nicolau syndrome, also known as livedo-like dermatitis or embolia cutis medicamentosa, is a rare complication following the intramuscular or intra-articular injection of various drugs. CASE PRESENTATION In our case report we report the case of a 45-year-old Turkish woman who developed Nicolau syndrome after an intramuscular injection in her right gluteal region of single-dose dic...

Il s’agit d’une fille âgée de 6 ans, suivie pour un rhumatisme articulaire aigu, mise sous benzathine-pénicilline toutes les 3 semaines, ayant présenté immédiatement après l’injection intramusculaire de benzathine-pénicilline une douleur intense de la fesse gauche, suivie 30 minutes plus tard par l’apparition d’une macule rouge violacée étendue au niveau de la fesse gauche associée à un rash cu...

Nicolau syndrome, also known as embolia cutis medicomentosa, is a rare complication characterized by tissue necrosis that occurs after injection of drugs. The exact pathogenesis is uncertain, but there are several hypotheses, including direct damage to the end artery and cytotoxic effects of the drug. Severe pain in the immediate postinjection period and purplish discoloration of the skin with ...