Embryo implantation is a crucial step in mammalian reproduction. However, little is known regarding the physiological roles of microRNAs in the regulation of embryo implantation. Here we show that a minimum uterine expression of miR-181 is essential for the onset of embryo implantation. Both transient and prolonged transgenic expression of miR-181 led to impaired implantation, which can be resc...

background: there is no doubt that luteal phase support is essential to enhance the reproductive outcome in ivf cycles. in addition to progesterone and human chorionic gonadotropin, several studies have described gnrh agonists as luteal phase support to improve implantation rate, pregnancy rate and live birth rate, whereas other studies showed dissimilar conclusions. all of these studies have b...

The endometrium is a highly dynamic tissue empowered with the capacity to undergo cyclic dramatic changes in response to ovarian steroid hormones, ultimately aiming to create a window of receptivity for blastocyst implantation. Intensive research has been performed to understand and establish morphological and molecular correlates of embryo implantation. However, it still remains a biological m...

The implantation of embryo depends on the quality of the embryo and the receptivity of the endometrium. While the factors affecting embryo quality were optimized, the implantation rates did not reach the desirable levels. This directs the blaming for endometrial receptivity which already has been affected by supra-physiological levels of hormone, namely estradiol, in controlled ovarian hypersti...

oocyte maturation and embryo development are controlled by intra-ovarian factors such as steroid hormones. progesterone (p4) exists in the follicular fluid that contributes to normal mammalian ovarian function and has several critical functions during embryo development and implantation, including endometrial receptivity, embryonic survival during gestation and transformation of the endometrial...

Background A major hurdle to improved in vitro fertilization (IVF) success rate is defective endometrial receptivity and implantation. Various techniques have been advocated to increase implantation while reducing side effects. Currently, embryo transfer (ET) is performed blindly without direct visualization. As such, we sought to develop a technique utilizing a flexible minihysteroscope with a...

background: recurrent implantation failure is one of the most issues in ivf cycles.some researchers found that beneficial effects of endometrial scratching in womenwith recurrent implantation failure, while some authors demonstrated contrary resultsobjective: the present study aimed to investigate the effect of intrauterine. salineinfusion as a form of endometrial injury, during fresh in vitro ...

Gap junctions play an important role in cell-to-cell communication, a process obviously required for embryo implantation. Uterine luminal epithelium (LE) is the first contact for an implanting embryo and is critical for the establishment of uterine receptivity. Microarray analysis of LE from periimplantation mouse uterus showed low level expression of 19 gap junction proteins in preimplantation...

Oocyte maturation and embryo development are controlled by intra-ovarian factors such as steroid hormones. Progesterone (P4) exists in the follicular fluid that contributes to normal mammalian ovarian function and has several critical functions during embryo development and implantation, including endometrial receptivity, embryonic survival during gestation and transformation of the endometrial...

background: in this study, we aimed to investigate the ability of transvaginal doppler ultrasonography in predicting in vitro fertilization (ivf) outcome in women undergoing this procedure. materials and methods: in this prospective observational study, 65 infertile women underwent ivf procedure in isfahan, during 2013-2014, were studied. the pulsatility index (pi), resistive index (ri) and pea...