the liquid metal flow and the solidification behaviours in a multi-cavity casting mould of two automotive cast parts were simulated in three dimensions. the commercial code, flow-3d® was used because it can track the front of the molten metal by a volume of fluid (vof) method and allows complicated parts to be modeled by the fractional area/volume obstacle representation (favor) method. the gre...

objective(s) ibuprofen is a problematic drug in tableting, and dissolution due to its poor solubility, hydrophobicity, and tendency to stick to surface. because of the bad compaction behavior ibuprofen has to be granulated usually before tableting. however, it would be more satisfactory to obtain directly during the crystallization step crystalline particles that can be directly compressed and ...

We propose a scheme for simulation of the solute-driven dendritic solidification which accounts for the flows of liquid and motion of growing dendrites. The scheme is based on the multiphase-field method for calculating the solidification and the lattice Boltzmann method to simulate the fluid flows. Motion and rotation of solid grains is possible.

The process of cast explosive solidification molding has been dynamic monitored by multi-channel ultrasonic transmission method. It presents the regular pattern of ultrasonic attenuation, velocity and waveform in this process. The results show that velocity values and waveform are relative to solidification speed and physical characterization on the phase border, and ultrasonic attenuation is r...

Background: Intravenous drug delivery is an advantageous choice for rapid administration, immediate drug effect, and avoidance of first-pass metabolism in oral drug delivery. In this study, the synthesis, formulation, and characterization of atorvastatin-loaded polyurethane (PU) nanoparticles were investigated for intravenous route of administration. Method: First, PU was synthesized and charac...

Gao and Sonin (1994) have proposed a method for rapid prototyping and microfabrication by precise deposition and solidification of molten microdrops. Objects can be fabricated by a drop-on-demand, computer-controlled droplet generator. To understand the fundamentals of droplet deposition and solidification, experiments have been conducted using microcrystalline wax droplets (Schiaffino and Soni...

Compositionally graded bulk materials of organic polymer blends were prepared by using nonequilibrium self-organization processes with a uniaxial thermal gradient (Bridgman method). The Bridgman method was firstly applied to prepare two kinds of polymeric compositionally graded materials: a polymer/low molecular weight additive system (poly(e-caprolactone) (PCL)/ 4,49-thiodiphenol (TDP)) and a ...

The solidification of gamma TiAl alloys is of interest to the aerospace and automotive industries. A gamma TiAl multicomponent alloy: Ti–45.5Al–4.7Nb–0.2C–0.2B (at. %) has been the focus of a study to investigate the solidification conditions that led to a Columnar to Equiaxed Transition (CET) in a directional solidification experiment where traditional Bridgman solidification was combined in s...

A new finite element level set method is developed to simulate the interface motion. The normal velocity of the moving interface can depend on both the local geometry, such as the curvature, and the external force such as that due to the flux from both sides of the interface of a material whose concentration is governed by a diffusion equation. The key idea of the method is to use an interface-...

Nanoparticle size is crucial to drug release behavior and biodistribution in vivo, but few studies have been performed on biodegradable nanoparticles with narrow size distribution. In this note, uniform-sized nanoparticles were prepared by a facile method combining emulsion-solvent removal and premix membrane emulsification for the first time. After preparation of coarse emulsions, additional p...