Chronic diseases such as diabetes mellitus and systemic hypertension have high prevalence all over the world. In majority of cases, patients having diabetes mellitus are also suffering from systemic hypertension and vice versa. Aims: The purpose of the study is to prepare a combination dosage form which can be used to treat both the diseases concomitantly, reducing pill burden and increasing pa...

INTRODUCTION The generic drugs program provided a better population's access to medicines. To ensure interchangeability between a brand-name and generic or similar drugs is necessary that they are bioequivalent. With the growing number of generic drugs, it is common for patients to replace a generic to another or one similar. However, this exchange can not guarantee the maintenance of bioequiva...

Article history: Received on: 08/09/2012 Revised on: 19/09/2012 Accepted on: 24/09/2012 Available online: 28/09/2012 A simple, precise and rapid reverse-phase HPLC method has been developed and subsequently validated for the simultaneous estimation of Amlodipine besylate and Enalapril maleate from their combination drug product. The proposed RP-HPLC method utilizes a Phenomenex C18, 5 μm, 250 m...

Hydrochlorothiazide (HCT) is a thiazide diuretic which reduces the resorption of electrolytes and consequently of water. Enalapril maleate (EM) is a derivative of 2 amino acids, L-alanine and L-proline, and is an antihypertensive and a vasodilator in congestive heart failure. The 2 drugs are used in association in the treatment of hypertension . Several methods are available in the literature f...

Four simple, rapid and sensitive spectrophotometric methods have been proposed for the determination of enalapril maleate in pharmaceutical formulations. The first method is based on the reaction of carboxylic acid group of enalapril maleate with a mixture of potassium iodate (KIO(3)) and iodide (KI) to form yellow colored product in aqueous medium at 25 +/- 1 degrees C. The reaction is followe...

Introduction: The generic drugs program provided a better population’s access to medicines. To ensure interchangeability between a brand-name and generic or similar drugs is necessary that they are bioequivalent. With the growing number of generic drugs, it is common for patients to replace a generic to another or one similar. However, this exchange can not guarantee the maintenance of bioequiv...

The aim of the present study was to formulate polymer microspheres using emulsion solvent evaporation technique as an approach mask bitter taste enalapril maleate. Five models were prepared with two water-insoluble polymers. Talc used stabilize particle structure. Production yields ranged from 38 % 53 %; drug loading varied between 17 and 40 mean size 140 μm 339 μm. No interaction polymers esti...

Enalapril maleate, the oldest and most widely distributed ACEI, and alacepril, the newest and antioxidant ACEI, were compared in the point of cardioprotective effect for Dahl salt-sensitive rat. In order to evaluate the correlation between the three factors, cardiac fibrosis and blood pressure/oxidative-stress marker (tissue TBARS), index of correlation was calculated. The results showed a sign...

Aim. To develop the composition and technology for obtaining combined drug of indapamide with enalapril prolonged action. Materials methods. Indapamide maleate substances as active components, polyvinylpyrrolidone, calcium stearate, lactose monohydrate, hydroxypropyl methylcellulose excipients were used. The pharmaco-technological studies conducted according to methods State Pharmacopoeia Ukrai...