نتایج جستجو برای: endophenotypes
تعداد نتایج: 1086 فیلتر نتایج به سال:
Endophenotypes are disease-associated phenotypes that are thought to reflect the neurobiological or other mechanisms that underlie the more overt symptoms of a psychiatric illness. Endophenotypes have been critical in understanding the genetics, neurobiology, and treatment of schizophrenia. Because psychiatric illnesses have multiple causes, including both genetic and nongenetic risk factors, a...
The use of endophenotypes has been proposed as a strategy to aid gene identification efforts for complex phenotypes [Gottesman, I. I., and Shields J. (1972). Schizophrenia and Genetics: A Twin Study Vantage Point. London: Academic]. As part of the Collaborative Study of the Genetics of Alcoholism (COGA) project, we have analyzed electrophysiological endophenotypes, in addition to clinical diagn...
objective: this study aimed to investigate the verbal memory and working memory impairment in healthy siblings of patients with schizophrenia. methods: the purpose of this study was to compare cognitive deficits in siblings of the patients with schizophrenia and control group. a total of 35 unaffected siblings of patients with schizophrenia were selected from the relatives of the patients refe...
INTRODUCTION The endophenotype research strategy aims at reducing complex clinical phenomena to reveal a more tractable mapping to underlying genes. Cognitive dysfunctions have been widely pursued as target endophenotype in schizophrenia. We critically discuss the promise and limitations of this approach. METHODS Relevant theoretical and empirical issues on genes and behaviour, neurocognitive...
Citation: Misiak B, Frydecka D and Rybakowski JK (2016) Editorial: Endophenotypes for Schizophrenia and Mood Disorders: Implications from Genetic, Biochemical, Cognitive, Behavioral, and Neuroimaging Studies. Front. Psychiatry 7:83. doi: 10.3389/fpsyt.2016.00083 Editorial: Endophenotypes for Schizophrenia and Mood disorders: implications from Genetic, Biochemical, Cognitive, Behavioral, and Neu...
a b s t r a c t “addiction” is a multifaceted complicated disorder with many interrelated causes, as well as environmental and genetic features. several hereditary variables that have an effect on these features might work in together to influence vulnerability and the extent of being an addict. molecular re-sequencing of the latest and formerly researched genes holds a crucial place with regar...
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