background: recently, it has been revealed that tyrosine kinase inhibitors (tkis) act through inducing both oxidative and endoplasmic reticulum (er) stress in chronic myeloid leukemia cells. however, er stress signaling triggers both apoptotic and survival processes within cells. nevertheless, mechanisms by which tkis avoid the pro-survival effects are not clear. the aim of this study was to ev...

The AN703 antibody, derived from the 221-42-1 hybridoma, detects PDI-containing endoplasmic reticulum of Dictyostelium discoideum by immunofluorescence.

Introduction: Intracellular pH (pHi) regulates essentially all aspects of cellular activities. However, it is unknown how endoplasmic reticulum (ER) potassium channels sense pHi. In this study, we investigate the direct effects of pHi on ER potassium channels. Methods: We used channel incorporation into the bilayer lipid membrane method. L-α-phosphatidylcholine, a membrane lipid, was extrac...

congenital generalized lipodystrophies (cgls) are very rare autosomal recessive disorders which have four types.of the four cgl types, bscl2 (berardinelli–seip congenital lipodystrophy type 2) is the result of mutations in the bscl2/seipingene.bscl2 which is the most severe lipodystrophic phenotype is characterized by generalized lipodystrophy, overgrowth,acanthosisnigricans, hepatomegaly, insu...

In this genetic study, Ctage5 and Tango1 endoplasmic reticulum cargo receptors were investigated together in vivo for the first time. Cell differentiation, survival, trafficking, stress pathway activation examined.

Effect of High Fat Diet and Endurance Training on the Gene Expression Sarco/Endoplasmic Reticulum ATPase2 (SERCA2) Ryanodine Receptor2 (RYR2) under Near-Thermoneutrality in Inguinal Adipose Tissue Mice

Ovine pulmonary adenocarcinoma (OPA) was studied in the lungs of 15 naturally-affected sheep (9 with classical and 6 atypical lesions) by transmission electron microscopy. Two lung samples from normal sheep were used to develop the ultrastructural criteria. Pathologic lesions consisted of focal-multifocal to coalescent nodules or masses in the cranioventral or diaphragmatic lobes. Ultrastructur...

Ema19 is an integral endoplasmic reticulum (ER) protein with relevance for mitochondrial biogenesis. This yeast, representative of the TMEM97/sigma 2 receptor family, serves as quality control factor which supports degradation nonimported proteins. study again demonstrates important role ER in targeting.

Introduction: we have recently reported the presence of two potassium currents with 598 and 368 pS conductance in the rough endoplasmic reticulum (RER) membrane. The 598 pS channel was voltage dependent and ATP sensitive. However, the 368 pS channel was rarely observed and its identity remained obscure. Since cationic channels in intracellular organelles such as mitochondria and RER play imp...