Payne GA, Bohlen HG, Dincer ÜD, Borbouse L, Tune JD. Periadventitial adipose tissue impairs coronary endothelial function via PKC-dependent phosphorylation of nitric oxide synthase. Am J Physiol Heart Circ Physiol 297: H460–H465, 2009. First published May 29, 2009; doi:10.1152/ajpheart.00116.2009.—Endogenous periadventitial adipose-derived factors have been shown to contribute to coronary vascu...

Endothelial nitric oxide synthase (eNOS) plays a critical role in regulating and maintaining healthy cardiovascular system. The importance of eNOS can be emphasized from the genetic polymorphisms gene, uncoupling dimerization, its numerous signaling regulations. activity on cardiac myocytes, vasculature, central nervous system are discussed. effects sympathetic autonomic (SANS) parasympathetic ...

Nitric oxide (NO) is a major regulatory molecule of the cardiovascular system; however, measurement of vascular NO synthesis in vivo represents a major challenge. NO stemming from the lower respiratory tract has been used as a marker of vascular endothelial function. Experimental evidence for this concept is lacking. Therefore, the aim of the present study was to investigate this relationship. ...

Background Endothelial cell nitric oxide synthase (eNOS), vascular endothelial growth factor

Endothelial Nitric Oxide Synthase (eNOS) produces nitric oxide (NO) from L-arginine and is important for the maintenance of cardiovascular homeostasis. Congestive heart failure (CHF) generally results in increased pulmonary blood flow and if untreated leads to pulmonary hypertension and end stage heart failure. We therefore hypothesized that increased pulmonary flow without changes in pres...

OBJECTIVE Nitric oxide produced by endothelial nitric oxide synthase (eNOS) possesses multiple anti-atherosclerotic properties. Hence, enhanced expression of eNOS and increased Nitric oxide levels may protect against the development of atherosclerosis. Piper sarmentosum is a tropical plant with antioxidant and anti-inflammatory activities. This study aimed to investigate the effects of Piper sa...

Introduction Sepsis is associated with high mortality rates as a result of the development of multiple organ failure (MOF). In MOF the competition for the amino acid arginine between the microcirculation and the inflammatory response is important. The endothelial nitric-oxide synthase (eNOS) uses arginine to produce nitric oxide (NO), which results in microcirculatory vasodilatation, whereas ar...

Background: Cyclosporine A (CsA) is an immunosuppressant with therapeutic indications in various immunological diseases; however, its use is associated with chronic nephropathy. Oxidative stress has a crucial role in CsA-induced nephrotoxicity. The present study evaluates the protective effect of edaravone on CsA-induced chronic nephropathy and investigates its antioxidant and nitric oxide modu...

endothelial nitric oxide synthase (enos) produces nitric oxide (no) from l-arginine and is important for the maintenance of cardiovascular homeostasis. congestive heart failure (chf) generally results in increased pulmonary blood flow and if untreated leads to pulmonary hypertension and end stage heart failure. we therefore hypothesized that increased pulmonary flow without changes in pressure ...

Systemic lupus erythematosus, in both animal models and in humans, is characterized by autoantibody production followed by immune complex deposition in target tissues. Ensuing target organ damage is modulated by reactive intermediates, including reactive nitrogen and oxygen species, through as of now incompletely understood mechanisms. Endothelial nitric oxide synthase is known to impact vascul...