Abstract Funding Acknowledgements Type of funding sources: None. Aim To investigate the role markers vascular inflammation, vitamin D, parathyroid hormone as predictors increased pulse-wave velocity (PWV) and degenerative bone changes in postmenopausal women with arterial hypertension (AH). Methods 164 females were examined. Gr.1 included 42 healthy individuals, Gr.2 - 58 patients AH Gr.3 64 os...

Chronic heart failure is one of the leading causes death globally, affecting 1.5 to 2% total world population and 2.9 3.9% Western European population. often progresses rapidly in coexistence with endocrine pathology, namely hypothyroidism, that results a more rapid development further progression endothelial dysfunction systemic inflammatory response. The aim our research was study levels endo...

Background. Atopic dermatitis is a chronic multifactorial dermatosis with complex pathophysiological basis. One of the poorly studied links in pathogenesis disease endothelin-1. Its main biological effects include pronounced vasoconstriction blood vessels.
 Aim. To study role endothelin-1 and its autoantibodies atopic dermatitis.
 Materials methods. The included 40 patients common lim...

The precursor of endothelin-1, big endothelin-1, can be hydrolyzed by chymase to generate endothelin-1 (1-31) in vitro. In the present study, we explored the processes involved in the production of endothelin-1 (1-31) as well as its pharmacodynamic characteristics in the rabbit in vivo. Endothelin-1 (1-31) (1 nmol/kg, injected into the left cardiac ventricle) induced a monophasic increase of me...