Cervical disc arthroplasty is a common method of treating cervical degenerative disease. However, the footprints of most prosthesis dimensions are obtained from data of Caucasian individuals. Besides, there is a large discrepancy between footprints of currently available cervical disc prostheses and anatomic dimensions of cervical endplates. We aimed to detail the three-dimensional (3D) anatomi...

OBJECTIVE Using alendronate after spinal fusion is a controversial issue due to the inhibition of osteoclast mediated bone resorption. In addition, there are an increasing number of reports that the endplate degeneration influences the lumbar spinal fusion. The object of this retrospective controlled study was to evaluate how the endplate degeneration and the bisphosphonate medication influence...

STUDY DESIGN One hundred and three lumbar intervertebral discs (L3/4-L5/S1) of 36 patients with low back pain were examined with computed tomography (CT) diskography and magnetic resonance imaging (MRI). OBJECTIVES To determine whether lumbar endplate degeneration correlates with the degree of disc degeneration or disc rupture and to determine if there is an association between pain provocati...

Impaired nutrition of the intervertebral disc has been hypothesized to be one of the causes of disc degeneration. However, no causal relationship between decreased endplate perfusion and limited nutrient transport has been demonstrated to support this pathogenic mechanism. To determine the importance of endplate perfusion on solute diffusion into the nucleus pulposus and to show causality of en...

After denervation, the number of acetylcholine receptors (AChR) found within the endplate band of skeletal muscle increases transiently by about twofold. In this study, we used EM autoradiography to show that this increased endplate band label is not due to an elevated site density of receptors at the junctional folds. Rather, AChR site density within 500 microns of the endplate was found to be...

Using the mouse passive transfer model the mean amplitude of miniature endplate potentials and endplate potentials of mice treated with myasthenic immunoglobulins was markedly decreased. Miniature endplate potential frequency and quantum content of endplate potentials were normal, arguing against a major presynaptic disarrangement. Under electron-microscopy no gross structural alterations of en...

The activity and properties of cholinesterase (ChE) of the motor endplate and its fractions were studied in isolated human skeletal muscle. This preparation was used since the ChE activity of the membrane preparation was localized only in the motor endplate. The endplate ChE was stable in the isolated membrane for 4 weeks at 4 degrees C. The specific activity of the extracted ChE of human muscl...

BACKGROUND In order to reduce the incidence of adjacent segment disease (ASD), the current study was designed to establish Chinese finite element models of normal 3rd~7th cervical vertebrae (C3-C7) and anterior cervical corpectomy and fusion (ACCF) with internal fixation , and analyze the influence of screw sagittal angle (SSA) on stress on endplate of adjacent cervical segments. METHODS Mimi...

(A) A T2 image of a human lumbar spine IVD disc. (B) FA map obtained from the DTI data. Notice the difference in FA signal between the anterior and posterior parts of the IVD with the yellow highlighted square indicating the lamellae’s anisotropic behavior, also viewed histologicaly in figure (C). Notice the substantial gaps between the lamellae appearing in this region. (D) The site of connect...

+*Guerin, H L; **Baxter, S; ***Nguyen, A; ***Elliott, D M; ***Villarraga, M L; ***Kurtz, S M +*Exponent, Inc., Philadelphia, PA [email protected] INTRODUCTION: The endplates of the intervertebral disc (IVD) distribute loads across the annulus fibrosus and nucleus pulposus (NP) structures of the disc, and have been shown to play an important role in the biomechanical behavior of the overall I...