Eighty four very low birthweight babies (considered high risk for developing necrotising enterocolitis) were given vancomycin orally for 48 hours before introduction of oral feeds; one developed necrotising enterocolitis. One hundred and twenty very low birthweight babies (not considered such high risk) were fed without first receiving vancomycin; 17 developed necrotising enterocolitis. Althoug...

BACKGROUND Patent ductus arteriosus is a risk factor for the development of necrotizing enterocolitis. The use of indomethacin to treat patent ductus arteriosus in preterm infants may either decrease the incidence of necrotizing enterocolitis by stabilizing or closing the ductus arteriosus or increase its incidence by a direct constricting effect on mesenteric blood vessels. The authors sought ...

Stat3 plays an essential role in IL-10 signaling pathways. A myeloid cell-specific deletion of Stat3 resulted in inflammatory cytokine production and development of chronic enterocolitis with enhanced Th1 responses in mice. In this study, we analyzed the mechanism by which a Stat3 deficiency in myeloid cells led to the induction of chronic enterocolitis in vivo. Even in the absence of Stat1, wh...

BACKGROUND Neutropenic enterocolitis is a life-threatening complication most frequently occurring after intensive chemotherapy in acute leukaemias. Gramnegative bacteria constitute the most important group of causative pathogens. Fungi have also been reported, but their practical relevance remains unclear. The guidelines do not address concrete treatment recommendations for fungal neutropenic e...

31 Jackman S, Brereton RJ, Wright VM. Results of surgical treatment of neonatal necrotizing enterocolitis. BrJ Surg 1990, 77: 146-8. 32 Smith SD, Tagge EP, Miller J, Cheu H, Sukarochana K, Rowe MI. The hidden mortality in surgically treated necrotizing enterocolitis: fungal sepsis. J Pediatr Surg 1990; 25: 1030-3. 33 Cikrit D, Mastandrea J, West KW, Schreiner RL, Grosfeld JL. Necrotizing entero...

31 Jackman S, Brereton RJ, Wright VM. Results of surgical treatment of neonatal necrotizing enterocolitis. BrJ Surg 1990, 77: 146-8. 32 Smith SD, Tagge EP, Miller J, Cheu H, Sukarochana K, Rowe MI. The hidden mortality in surgically treated necrotizing enterocolitis: fungal sepsis. J Pediatr Surg 1990; 25: 1030-3. 33 Cikrit D, Mastandrea J, West KW, Schreiner RL, Grosfeld JL. Necrotizing entero...

BACKGROUND/PURPOSE Chronic or recurring enterocolitis is a rare but perplexing complication of Hirschsprung's disease affecting especially patients with altered immune defense such as those with Down's syndrome. Sodium cromoglycate (SCG) is a nonabsorbable mast cell stabilizing agent that has been documented to be effective in the treatment of inflammatory bowel disease. The authors studied the...

AIMS To evaluate the effectiveness of oral vancomycin in the prophylaxis of necrotising enterocolitis in preterm, very low birthweight infants. METHODS A prospective, double blind, randomised, placebo controlled study in a tertiary referral centre of a university teaching hospital was conducted on 140 very low birthweight infants consecutively admitted to the neonatal unit. The babies were ra...