PURPOSE Nephrotic syndrome is a common chronic illness encountered during childhood. Infections have been identified as a cause of nephrotic syndrome. The aim of this study was to evaluate the association between enteroviral infection and nephrotic syndrome. METHODS A nationwide retrospective cohort study was conducted by analyzing data from the National Health Insurance Research Database in ...

Karita Sadeharju: Maternal and childhood enterovirus infections and the risk of beta-cell autoimmunity Type 1 diabetes is a chronic disease, which is caused by the destruction of insulin producing pancreatic beta-cells. Beta-cells are destroyed by immune mediated mechanisms and the disease is classified as an autoimmune disease. The pathogenesis of the disease is multifactorial. Genetic suscept...

Abstract To determine the effects of nonpharmaceutical interventions (NPIs) for coronavirus disease on pediatric hospitalizations infection with respiratory viruses other than severe acute syndrome 2, we analyzed hospital data 2017–2021. Compared 2017–2019, age-specific hospitalization rates associated greatly decreased in 2020, when NPIs were place. Also place, among children all ages influenz...

Previous studies have suggested that enterovirus infections during pregnancy may increase the risk of type 1 diabetes in the offspring. Our aim was to evaluate the role of first trimester enterovirus infections in a larger cohort of pregnant women. Two series of pregnant women were analyzed as follows: 948 women (series 1) and 680 women (series 2) whose child developed clinical diabetes before ...

The clinical impact of enteroviruses associated with hand, foot and mouth disease (HFMD) is unknown outside Asia, and the prevalence of enterovirus A71 (EV-A71) in particular might be underestimated. To investigate the prevalence of enterovirus serotypes and the clinical presentations associated with HFMD in France, we conducted prospective ambulatory clinic-based surveillance of children durin...

Sequencing of the gene that encodes the capsid protein VP1 has been used as a surrogate for antigenic typing in order to distinguish enterovirus serotypes; three new serotypes were identified recently by this method. In this study, 14 enterovirus isolates from six countries were characterized as members of two new types within the species Human enterovirus B, based on sequencing of the complete...

background human enteroviruses are members of picornaviridae family; they are non-enveloped, icosahedral viruses with positive rna as genome. echovirus 30 is an important member of enteroviruses that is recognized in outbreaks of enterovirus meningitis. objectives the aim of this study was to determine relative frequency of echovirus 30 as an important agent of aseptic meningitis among children...

OBJECTIVE To detect and characterise enterovirus RNA in skeletal muscle from patients with chronic fatigue syndrome (CFS) and to compare efficiency of muscle energy metabolism in enterovirus positive and negative CFS patients. METHODS Quadriceps muscle biopsy samples from 48 patients with CFS were processed to detect enterovirus RNA by two stage, reverse transcription, nested polymerase chain...

BACKGROUND Enterovirus D68 (EV-D68) resulted in a reported increase in the number of children needing hospital or critical care admission because of respiratory insufficiency during 2014. It remains unclear, however, whether EV-D68 infections were more severe than rhinovirus or non-EV-D68 enterovirus infections. METHODS We evaluated consecutive children presenting to a pediatric hospital betw...

OBJECTIVES An unexpectedly high proportion of children were admitted for severe respiratory infections at the Oslo University Hospital, Ullevål, Norway, during September and October, 2014. In light of the ongoing outbreak of enterovirus-D68 (EV-D68) in North America a real-time RT-PCR for screening of enterovirus and enterovirus D68 was established. DESIGN We developed a duplex real-time RT-P...