نتایج جستجو برای: entorhinal cortex

تعداد نتایج: 145013  

Journal: :AJNR. American journal of neuroradiology 2017
A A Thaker B D Weinberg W P Dillon C P Hess H J Cabral D A Fleischman S E Leurgans D A Bennett B T Hyman M S Albert R J Killiany B Fischl A M Dale R S Desikan

BACKGROUND AND PURPOSE The entorhinal cortex, a critical gateway between the neocortex and hippocampus, is one of the earliest regions affected by Alzheimer disease-associated neurofibrillary tangle pathology. Although our prior work has automatically delineated an MR imaging-based measure of the entorhinal cortex, whether antemortem entorhinal cortex thickness is associated with postmortem tan...

Journal: :Seizure 2000
Tuuli Salmenperä Reetta Kälviäinen Kaarina Partanen Asla Pitkänen

The entorhinal cortex (Brodmann's area 28) is located at the anterior aspect of the parahippocampal gyrus ventral to the amygdala and the hippocampus. It is reciprocally interconnected with the hippocampus via glutamatergic pathways. We investigated whether the entorhinal cortex is damaged in human temporal lobe epilepsy (TLE). The volume of the entorhinal cortex was measured using magnetic res...

Journal: :Science 2004
Marianne Fyhn Sturla Molden Menno P Witter Edvard I Moser May-Britt Moser

As the interface between hippocampus and neocortex, the entorhinal cortex is likely to play a pivotal role in memory. To determine how information is represented in this area, we measured spatial modulation of neural activity in layers of medial entorhinal cortex projecting to the hippocampus. Close to the postrhinal-entorhinal border, entorhinal neurons had stable and discrete multipeaked plac...

Journal: :Neurology 2000
Y Xu C R Jack P C O'Brien E Kokmen G E Smith R J Ivnik B F Boeve R G Tangalos R C Petersen

OBJECTIVE MRI-based measurements of hippocampal atrophy are a sensitive indicator of the early pathologic degeneration of the medial temporal lobe in AD. However, AD pathology appears first in the transentorhinal/entorhinal cortex, not the hippocampus. The authors tested the hypothesis that MRI-based measurements of the entorhinal cortex are more sensitive than measurements of hippocampal volum...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
M Barbarosie M Avoli

Continuous application of 4-aminopyridine (4-AP, 50 microM) to combined slices of hippocampus-entorhinal cortex obtained from adult mice induces (1) interictal discharges that initiate in the CA3 area and propagate via the hippocampal regions CA1 and subiculum to the entorhinal cortex and return to the hippocampus through the dentate gyrus; and (2) ictal discharges that originate in the entorhi...

Journal: :Journal of neurophysiology 2004
Douglas A Caruana C Andrew Chapman

Although a major output of the hippocampal formation is from the subiculum to the deep layers of the entorhinal cortex, the parasubiculum projects to the superficial layers of the entorhinal cortex and may therefore modulate how the entorhinal cortex responds to sensory inputs from other cortical regions. Recordings at multiple depths in the entorhinal cortex were first used to characterize fie...

Journal: :The Journal of comparative neurology 1998
R D Burwell D G Amaral

The cortical regions dorsally adjacent to the posterior rhinal sulcus in the rat can be divided into a rostral region, the perirhinal cortex, which shares features of the monkey perirhinal cortex, and a caudal region, the postrhinal cortex, which has connectional attributes similar to the monkey parahippocampal cortex. We examined the connectivity among the rat perirhinal (areas 35 and 36), pos...

Journal: :Alzheimer's & dementia : the journal of the Alzheimer's Association 2013
Vanessa A Guzman Owen T Carmichael Christopher Schwarz Giuseppe Tosto Molly E Zimmerman Adam M Brickman

BACKGROUND Current hypothetical models of Alzheimer's disease (AD) pathogenesis emphasize the role of β-amyloid (Aβ), tau deposition, and neurodegenerative changes in the mesial temporal lobe, particularly the entorhinal cortex and hippocampus. However, many individuals with clinical AD who come to autopsy also exhibit cerebrovascular disease. The relationship between AD and vascular pathology ...

Journal: :Journal of neurophysiology 2010
Gerardo Biella Paolo Spaiardi Mauro Toselli Marco de Curtis Vadym Gnatkovsky

The massive transfer of information from the neocortex to the entorhinal cortex (and vice versa) is hindered by a powerful inhibitory control generated in the perirhinal cortex. In vivo and in vitro experiments performed in rodents and cats support this conclusion, further extended in the present study to the analysis of the interaction between the entorhinal cortex and other parahippocampal ar...

2016
Taylor W Schmitz R Nathan Spreng

There is considerable debate whether Alzheimer's disease (AD) originates in basal forebrain or entorhinal cortex. Here we examined whether longitudinal decreases in basal forebrain and entorhinal cortex grey matter volume were interdependent and sequential. In a large cohort of age-matched older adults ranging from cognitively normal to AD, we demonstrate that basal forebrain volume predicts lo...

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