conclusions the results of the present investigation suggest that sac could be used as a food supplement in the treatment of diabetes characterized by provoked antioxidant status, altered blood glucose, and hormones level. results the levels of glucose, cyp2e1 activity, thiobarbituric acid reactive substances (tbars), hydroperoxide, and ceruloplasmin were increased significantly; whereas, the l...

In vitro maturation (IVM) is emerging as a popular technology at the forefront of fertility treatment and preservation. However, standard in vitro culture conditions usually increase reactive oxygen species (ROS), which have been implicated as one of the major causes for reduced embryonic developmental competence. It is well-known that higher than physiological levels of ROS triggers granulosa ...

The study was designed to assess the antioxidant defense mechanisms, either enzymatic or non-enzymatic, in a group of sixteen centenarians (one male and fifteen female subjects aged 101 to 105 years) living in the Upper Silesia district (Poland) in order to evaluate the potential role of antioxidant defenses in human longevity. The results of our preliminary study showed that in comparison with...

Free radicals are substances normally produced by the human body as one of the defense mechanisms against harmful substances. When the rate of their production exceeds the antioxidant capacity of the body, oxidative stress occurs. Oxidative stress carries harmful effects to all the body systems and is implicated in the pathogenesis of various diseases including hypertension, atherosclerosis, di...

Diabetes is a multifaceted disease occurring due to defective synthesis or action of insulin and as it progresses, complications develops which are associated with oxidative stress and decreased level of antioxidants. Hence this study was carried out to evaluate the levels of MDA and antioxidants like GSH, GPx, Gred, SOD during early phase of the disease(recently diagnosed) in diabetic individu...

The aim of the study was the evaluation of cadmium effects on the activity of antioxidant enzymes in rat hepatocytes. The studies were conducted with isolated rat hepatocytes incubated for 1 or 2 hours in a modified (deprived of carbonates with phosphates) Williams' E medium (MWE) in the presence of cadmium chloride (25, 50 and 200 microM). Hepatocytes incubated in the MWE medium without cadmiu...

*Correspondence: Bojjam V. Vardhini, Department of Botany, Telangana University, Dichpally, Nizamabad 503322, India e-mail: drvidyavardhini@ rediffmail.com Various abiotic stress factors significantly contribute to major worldwide-losses in crop productivity by mainly impacting plant’s stress tolerance/adaptive capacity. The latter is largely governed by the efficiency of antioxidant defense sy...

Stress has been shown to be associated with altered homeostasis that may lead to oxidant-antioxidant imbalance. Non-enzymatic antioxidants are important regulators of reactive oxygen species produced in extra-cellular milieu and represent the first line of defense against them. Extra-cellular non-enzymatic antioxidants may be disturbed by the production of superoxide and nitric oxide and this h...

Heavy metal stress induced alterations in the activities of several representatives of the enzymatic antioxidant defense system such as guiacol peroxidase (POD), catalase (CAT) and ascorbate peroxidase (APX) were comparatively studied in barley seedlings treated by Zn and Cd. Although roots were the main sites of metal accumulation, the oxidative damage was detrimental mainly in the leaves. Our...

INTRODUCTION Chronic myeloid leukaemia (CML) is a myeloproliferative disorder of the haematopoietic cell. Free radicals can be important causative agents of a number of human diseases, including cancer and leukaemia. Thus, antioxidants, which control the oxidative stress state, represent a major line of defense for regulating the overall true state of health. The relationship between non-enzyma...