This work introduces three eco-friendly UV spectrophotometric methods for the simultaneous estimation of Paracetamol, Aceclofenac and Eperisone Hydrochloride in pharmaceutical tablet formulation. The procedures employed were equation method multivariate chemometric with phosphate buffer pH 7.80 as diluent. encompasses absorbance measurement at different wavelengths (λmax drugs). It exhibits lin...

Eperisone and afloqualone act by relaxing both skeletal and vascular smooth muscles to improve circulation and suppress pain reflex. These drugs are typically prescribed with non-steroidal anti-inflammatory drugs (NSAIDs) as painkillers. However, there have been no reports on serious adverse reactions to oral muscle relaxants; and this is the first report to describe three allergic reactions ca...

Objective: The current work involves formulation development of nanostructured lipid carrier (NLC) eperisone hydrochloride (EPE) using quality by design (QbD) approach.
 Materials and Methods: Initial screening solid liquid lipids was performed based on the Hansen solubility parameters EPE later confirmed saturation studies. optimum identified three-squared randomized full factorial design...

Electrophysiological studies were performed to elucidate the mechanism underlying the antivertigo action of eperisone, an antispastic drug, using cats anesthetized with alpha-chloralose. Iontophoretic application of eperisone up to 100 nA produced a dose-dependent inhibition of spike generation upon vestibular nerve stimulation in monosynaptic and polysynaptic neurons of the medial vestibular n...

spectrometry (LC–ESI-MS) method for determination of eperisone in human plasma using buflomedil as the internal standard (IS) is established. After being made alkaline with saturated sodium bicarbonate solution, plasma samples are extracted with a mixture of diethyl ether–cyclohexane (1:1, v/v) and separated by highperformance liquid chromatography on a reversed-phase C1 8 column with a mobile ...

Objectives: to evaluate efficacy and tolerability of two different dosages of eperisone (150 and 300 mg/day) in comparison with those of diazepam 15 mg/day, orally given for seven days. Methods: Spontaneous and provoked pain, muscular contracture and its impact on working capacity as well as “hand-to-floor” distance and degree of lumbar tract flexion were assessed in a randomised double-blind t...

The effects of eperisone, an antispasmodic, on the electrical and mechanical properties of smooth muscle cells of the guinea-pig basilar artery were investigated. Eperisone (below 50 microM) did not modify the membrane potential, membrane resistance, excitatory junction potential evoked by perivascular nerve stimulation or the K- and 5-hydroxytryptamine-induced depolarizations. However, in conc...