Epithelial dysplasia is frequently seen adjacent to cholangiocarcinoma in the intra' and extrahepatic bile ducts' and carcinoma of the gall bladder which has a similar epithelial lining.' Extensive severe epithelial dysplasia involving the gall bladder, cystic duct, and common bile duct, associated with adenocarcinoma of the common hepatic duct, was recently reported in a patient with primary s...

The Fifth edition of the World Health Organization classification digestive system and American Joint Committee on Cancer staging manual contain substantial refinements information for esophageal tumors. epithelial tumors esophagus are classified as benign, dysplasia, malignant groups. Dysplasia is divided into Barrett dysplasia squamous graded either low-grade or high-grade. Malignant often ad...

BACKGROUND Ovarian epithelial dysplasia was first described after prophylactic oophorectomies for genetic risk. Ovarian stimulation has been considered as a risk factor of ovarian cancer by Fathalla's incessant ovulation theory. In this study, we have investigated the risk of ovarian dysplasia after ovulation induction. METHODS We reviewed 99 oophorectomies or cystectomies between 1990 and 20...

Chronic atrophic gastritis, chronic duodenal and gastric ulcers create conditions for the formation of precancerous changes in mucosa form dysplasia. The biopsy material from patients with - 75 was studied. development severe dysplasia epithelium observed mainly more forms gastritis. High proliferative activity confirmed by expression marker Ki-67 a label index (MI)>30,0%. Between degree muc...

Paired-like homeodomain 1 (PITX1) genes are essential in human development. In the present study, PITX1 protein expression was evaluated in human normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma (OSCC), with the aim of examining the expression patterns of these critical genes during the multi-stage transformation of oral epithelial dysplasia to OSCC. PITX1 and Ki-6...

BACKGROUND Although oral lichen planus has been classified by the World Health Organization (WHO) as a potentially malignant disorder, such classification is still the target of much controversy. AIM To evaluate the cell proliferation rate in oral lichen planus, comparing it to the rate observed in epithelial dysplasia and oral squamous cell carcinoma, aiming at indications which might indica...

Objective: The diagnosis of epithelial dysplasia at the surgical margins in oral cancer plays an important role in its prognosis and requires careful evaluation. Epithelial dysplasia is usually asymptomatic, but often associated with recurrence and malignant transformation. Patients and Methods: The patients included 9 men and 5 women (mean age, 54.6 years; range, 31 to 76 years) with early ton...

Purpose: Inactivation of p16 gene by CpG methylation is a frequent event in oral epithelial dysplasia. To investigate the predictive value of p16 methylation on malignant potential in oral epithelial dysplasia, we carried out the prospective cohort study. Experimental Design: One hundred one patients with histologically confirmed mild or moderate oral epithelial dysplasia were included in the p...