A highly efficient catalytic kinetic resolution of 2,3-epoxy 3-aryl ketones via asymmetric ring-opening with pyrazole derivatives has been achieved by using a chiral N,N'-dioxide-Sc(III) complex as the catalyst. A wide variety of substrates were readily scoped, and the selectivity factors obtained were excellent (up to >300).

The radical chemistry has become an inevitable tool to the organic chemists now a days for the formation of carbon-carbon bonds. Prolific use of this particular field of chemistry is well established and growing continuously for the synthesis of carbocyclic as well as heterocyclic natural products. High stereo-and regioselectivity and mildness of the radical technique unaffecting various sensit...

The synthesis of previously undescribed 22- and 23-deoxyanalogues homocastasterone has been carried out, which makes it possible to obtain target compounds without replacing the carbon skeleton side chain. key reactions in their were epoxy ring opening radical debromination.

A mild, green and highly efficient route for regio-selective amination of oxiranes was developed via incorporation of Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) cations onto the surface of hydroxyapatite-encapsulated γ-Fe2O3 nanoparticles (γ-Fe2O3@HAp). Among six magnetically recoverable catalytic systems denoted as [γ-Fe2O3@HAp-MII], the catalyst in which M designated as Fe(II) showed t...

an efficient and simple method for the preparation of si-imidazole-hso4 functionalized magnetic fe3o4 nanoparticles (si-im-hso4 mnps) and used as an efficient and reusable magnetic catalysts for the regioselective ring opening of epoxides under green conditions in water. this catalyst was used for the ring opening of epoxide corresponding to the thiocyanohydrins and azidohydrines. compared to t...

polydimethylsiloxane (pdms) has been synthesized by ring-opening polymerization of octamethylcyclotetrasiloxane (d4) in microemulsion with acidic catalyst. the structure and properties of microemulsion were characterized by transmission electron microscopy (tem), fourier transform infrared spectroscopy (ft-ir), photo correlation spectroscopy (pcs). the effect of the variation in ph value, amoun...

The nucleophilic ring opening of epoxy fatty esters was carried out using the amino-1,2,4-triazole to yield substituted derivatives of β-amino alcohol. The synthesis of the substituted beta amino alcohols has been achieved by refluxing equimolar quantities of long chain epoxy esters (epoxy fatty esters) and 4-amino-1,2,4-triazole in dichloromethane to yield following compounds, methyl 10-(4'-am...

A convinent and efficient method was developed for the synthesis of 1,2-azidoalcohols by ring opening of terminal epoxides with sodium azide employing glycerol-based sulphonic acid functionalized carbon as heterogeneous catalyst in aqueous acetonitrile. The reaction is highly regioselective and affords the corresponding products in excellent yields (78-100%) under mild reaction conditions. The ...