Background: Scleroderma is a chronic systemic disorder that affects the connective tissues. It is characterized by several immune manifestations, inflammation, vascular damage, and fibrosis. Some of the viral infections with complex mechanisms are involved in the development and progression of many autoimmune diseases, such as scleroderma. The present study aimed to investigate the serological ...

results there was a significant difference in prevalence of ebv presence between patients and controls. the ebv was found by rt-pcr in 19 (63.33%) out of 30 patients and only in eight (26.7%) of 30 control samples. the p = 0.004, was calculated using chi-square test (or: 4.75; 95% ci: 1.58 ‒ 14.25). conclusions our study is the first investigation performed on patients with lch and its possible...

INTRODUCTION: Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are herpesviruses, which account for the majority of oral viral infections. Herpes simplex virus, varicellazoster virus, and Epstein-Barr virus infections nearly always result from reactivation of latent virus, while cytomegalovirus infections, besides presenting as reactivated disease, are almost as likely to present as a primary...

background: oral lichen planus (olp) is a chronic immunologic disease. the etiology of olp is unknown, viral antigens (for example epstein-bar virus) have been proposed as etiologic agents. olp may get transformation to malignancy so re search on the presence of ebv in olp lesions seems to be necessary. the aim of this study was to ascertain if ebv acted as etiologic factor in pathogenesis of o...

colorectal cancer is the most common gastrointestinal cancer and the second leading cause of cancer deaths worldwide. the purpose of this study is to investigate the prevalence of epstein-barr virus in patients with colorectal carcinomas and polyps in comparison with healthy people. in this analytical  case-control study, 15 patients with colorectal cancer and 20 patients with colorectal polyp ...

Immunoglobulin M (IgM) antibodies to Epstein-Barr virus were detected by using microtiter plates coated with anti-mu-chain antiserum and enzyme-labeled Epstein-Barr virus antigen. Optimum conditions for labeling were determined. The addition of unlabeled control antigen to the enzyme-labeled antigen was effective in reducing background reactions. Rheumatoid factor no longer interfered. Blocking...

A technique using indirect immunoperoxidase antibody was developed for the detection of specific serum IgA antibody to Epstein-Barr virus capsid antigen and early antigen. The IgA technique was compared with an immunofluorescence antibody method. Epstein-Barr virus IgA antibody against viral capsid antigen was detected in all nine patients with Epstein-Barr virus associated undifferentiated nas...

background and objectives: epstein barr virus (ebv) is one of the members of herpesviridae family and a sub-category of gamma herpes virinae. ebv, which normally has cr2 or cd21 receptors on b-lymphocytes, has mutagenic features for them. the virus plays an important role in causing some malignant cancers. about 30% of the cases with non-hodgkin’s lymphoma are diffuse large b-cell lymphoma (dlb...

background epstein barr virus (ebv) is one of the most common viral infections in human population. ebv has a significant role in pathogenesis of hodgkin's lymphoma, burkitt's lymphoma and nasopharyngeal carcinoma. the role of ebv in non-hodgkin’s lymphoma, diffuse large b cell (nhl - dlbl) in the head and neck is controversial. objectives the purpose of this study is to find out the ...

The immune adherence hemagglutination assay was found to be as sensitive and specific as the indirect immunofluorescence technique for titration of antibodies to Epstein-Barr virus capsid antigen. Satisfactory virus capsid antigen-specific and negative control antigens for the immune adherence hemagglutination assay were prepared from cell extracts of the Epstein-Barr virus producer P3HR-1 and ...